RGS8

Regulator of G-protein signaling 8

PDB rendering based on 2ihd.

Available structures
PDB	2IHD, 2ODE

Identifiers

Symbols

RGS8; MGC119067; MGC119068; MGC119069

External IDs

OMIM: 607189 HomoloGene: 23152 GeneCards: RGS8 Gene

Gene Ontology
Molecular function	• signal transducer activity • GTPase activator activity
Cellular component	• cytoplasm • plasma membrane
Biological process	• negative regulation of signal transduction • positive regulation of GTPase activity
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
182.62 – 182.65 Mb

Chr 1:
155.5 – 155.54 Mb

PubMed search

[1]

[2]

Regulator of G-protein signaling 8 is a protein that in humans is encoded by the RGS8 gene.^[1]^[2]

This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation.^[2]

References

^ Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, Morgenbesser SD, Su K, Faruque MU, Pinkett H, Graham C, Baxevanis AD, Klinger KW, Landes GM, Trent JM, Carpten JD (Apr 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus". Genomics 73 (2): 211–22. doi:10.1006/geno.2001.6500. PMID 11318611.
^ ^a ^b "Entrez Gene: RGS8 regulator of G-protein signalling 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85397.

Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human.". Genomics 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
Saitoh O, Murata Y, Odagiri M, et al. (2002). "Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling.". Proc. Natl. Acad. Sci. U.S.A. 99 (15): 10138–43. doi:10.1073/pnas.152085999. PMC 126637. PMID 12110731. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126637.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Masuho I, Itoh M, Itoh H, Saitoh O (2004). "The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression.". J. Neurochem. 88 (1): 161–8. doi:10.1046/j.1471-4159.2003.02139.x. PMID 14675160.
Larminie C, Murdock P, Walhin JP, et al. (2004). "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system.". Brain Res. Mol. Brain Res. 122 (1): 24–34. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813.
Saitoh O, Yoshihiro K (2005). "Biochemical and electrophysiological analyses of RGS8 function.". Meth. Enzymol. 390: 129–48. doi:10.1016/S0076-6879(04)90009-2. PMID 15488175.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Benians A, Nobles M, Tinker A (2005). "Participation of RGS8 in the ternary complex of agonist, receptor and G-protein.". Biochem. Soc. Trans. 32 (Pt 6): 1045–7. doi:10.1042/BST0321045. PMID 15506959.
Benians A, Nobles M, Hosny S, Tinker A (2005). "Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics.". J. Biol. Chem. 280 (14): 13383–94. doi:10.1074/jbc.M410163200. PMID 15677457.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.

PDB gallery

2ihd: Crystal structure of Human Regulator of G-protein signaling 8, RGS8

2ode: Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3

RGS8

References

Further reading