RGS7

Regulator of G-protein signaling 7

PDB rendering based on 2a72.

Available structures
PDB	2A72, 2D9J

Identifiers

Symbols

RGS7;

External IDs

OMIM: 602517 MGI: 1346089 HomoloGene: 2193 GeneCards: RGS7 Gene

Gene Ontology
Molecular function	• signal transducer activity • GTPase activator activity • protein binding
Cellular component	• cellular_component • cytoplasm • heterotrimeric G-protein complex • plasma membrane
Biological process	• regulation of G-protein coupled receptor protein signaling pathway • negative regulation of signal transduction • intracellular signal transduction • positive regulation of GTPase activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
240.93 – 241.52 Mb

Chr 1:
176.99 – 177.42 Mb

PubMed search

[1]

[2]

Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene.^[1]^[2]

Interactions

RGS7 has been shown to interact with PKD1,^[3] GNB5^[4]^[5] and SNAPAP.^[6]

References

^ Koelle MR, Horvitz HR (Feb 1996). "EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins". Cell 84 (1): 115–25. doi:10.1016/S0092-8674(00)80998-8. PMID 8548815.
^ "Entrez Gene: RGS7 regulator of G-protein signalling 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6000.
^ Kim, E; Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme V P, Walz G (May. 1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (11): 6371–6. doi:10.1073/pnas.96.11.6371. ISSN 0027-8424. PMC 26888. PMID 10339594. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26888.
^ Levay, K; Cabrera J L, Satpaev D K, Slepak V Z (Mar. 1999). "Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (5): 2503–7. doi:10.1073/pnas.96.5.2503. ISSN 0027-8424. PMC 26814. PMID 10051672. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26814.
^ Posner, B A; Gilman A G, Harris B A (Oct. 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. (UNITED STATES) 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. ISSN 0021-9258. PMID 10521509.
^ Hunt, Rachel A; Edris Wade, Chanda Pranab K, Nieuwenhuijsen Bart, Young Kathleen H (Apr. 2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. (United States) 303 (2): 594–9. doi:10.1016/S0006-291X(03)00400-5. ISSN 0006-291X. PMID 12659861.

Shuey DJ, Betty M, Jones PG et al. (1998). "RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells". J. Neurochem. 70 (5): 1964–72. doi:10.1046/j.1471-4159.1998.70051964.x. PMID 9572280.
Levay K, Cabrera JL, Satpaev DK, Slepak VZ (1999). "Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2503–7. doi:10.1073/pnas.96.5.2503. PMC 26814. PMID 10051672. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26814.
Saitoh O, Kubo Y, Odagiri M et al. (1999). "RGS7 and RGS8 differentially accelerate G protein-mediated modulation of K+ currents". J. Biol. Chem. 274 (14): 9899–904. doi:10.1074/jbc.274.14.9899. PMID 10092682.
Kim E, Arnould T, Sellin L et al. (1999). "Interaction between RGS7 and polycystin". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6371–6. doi:10.1073/pnas.96.11.6371. PMC 26888. PMID 10339594. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26888.
Snow BE, Betts L, Mangion J et al. (1999). "Fidelity of G protein β-subunit association by the G protein γ-subunit-like domains of RGS6, RGS7, and RGS11". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6489–94. doi:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26909.
Posner BA, Gilman AG, Harris BA (1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". J. Biol. Chem. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509.
Benzing T, Yaffe MB, Arnould T et al. (2000). "14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity". J. Biol. Chem. 275 (36): 28167–72. doi:10.1074/jbc.M002905200. PMID 10862767.
Rose JJ, Taylor JB, Shi J et al. (2000). "RGS7 is palmitoylated and exists as biochemically distinct forms". J. Neurochem. 75 (5): 2103–12. doi:10.1046/j.1471-4159.2000.0752103.x. PMID 11032900.
Zhang JH, Barr VA, Mo Y et al. (2001). "Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain". J. Biol. Chem. 276 (13): 10284–9. doi:10.1074/jbc.M009247200. PMID 11152459.
Benzing T, Köttgen M, Johnson M et al. (2002). "Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha". J. Biol. Chem. 277 (36): 32954–62. doi:10.1074/jbc.M200859200. PMID 12077120.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Hunt RA, Edris W, Chanda PK et al. (2003). "Snapin interacts with the N-terminus of regulator of G protein signaling 7". Biochem. Biophys. Res. Commun. 303 (2): 594–9. doi:10.1016/S0006-291X(03)00400-5. PMID 12659861.
Witherow DS, Tovey SC, Wang Q et al. (2003). "G beta 5.RGS7 inhibits G alpha q-mediated signaling via a direct protein-protein interaction". J. Biol. Chem. 278 (23): 21307–13. doi:10.1074/jbc.M212884200. PMID 12670932.
Anderson NL, Polanski M, Pieper R et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Takida S, Fischer CC, Wedegaertner PB (2005). "Palmitoylation and Plasma Membrane Targeting of RGS7 Are Promoted by αo". Mol. Pharmacol. 67 (1): 132–9. doi:10.1124/mol.104.003418. PMC 1405920. PMID 15496508. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1405920.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Drenan RM, Doupnik CA, Jayaraman M et al. (2006). "R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism". J. Biol. Chem. 281 (38): 28222–31. doi:10.1074/jbc.M604428200. PMID 16867977.

PDB gallery

2a72: Structure of the regulator of G-protein signaling domain of RGS7

2d9j: Solution structure of the RGS domain of Regulator of G-protein signaling 7

RGS7

Interactions

References

Further reading