RGS3

Regulator of G-protein signaling 3

PDB rendering based on 2f5y.

Available structures
PDB	2F5Y, 2OJ4, 3FBK

Identifiers

Symbols

RGS3; C2PA; FLJ20370; FLJ31516; FLJ90496; PDZ-RGS3; RGP3

External IDs

OMIM: 602189 MGI: 1354734 HomoloGene: 32440 GeneCards: RGS3 Gene

Gene Ontology
Molecular function	• signal transducer activity • GTPase activator activity
Cellular component	• nucleus • cytoplasm • cytosol • plasma membrane
Biological process	• inactivation of MAPK activity • regulation of G-protein coupled receptor protein signaling pathway • negative regulation of signal transduction • positive regulation of GTPase activity • positive regulation of GTPase activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
116.21 – 116.36 Mb

Chr 4:
62.22 – 62.36 Mb

PubMed search

[1]

[2]

Regulator of G-protein signaling 3 is a protein that in humans is encoded by the RGS3 gene.^[1]^[2]^[3]

This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.^[3]

References

^ Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature 379 (6567): 742–6. doi:10.1038/379742a0. PMID 8602223.
^ Linares JL, Wendling C, Tomasetto C, Rio MC (Nov 2000). "C2PA, a new protein expressed during mouse spermatogenesis". FEBS Lett 480 (2–3): 249–54. doi:10.1016/S0014-5793(00)01942-6. PMID 11034339.
^ ^a ^b "Entrez Gene: RGS3 regulator of G-protein signalling 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5998.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Chatterjee TK, Eapen A, Kanis AB, Fisher RA (1998). "Genomic organization, 5'-flanking region, and chromosomal localization of the human RGS3 gene". Genomics 45 (2): 429–33. doi:10.1006/geno.1997.4929. PMID 9344672.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Dulin NO, Sorokin A, Reed E et al. (1999). "RGS3 Inhibits G Protein-Mediated Signaling via Translocation to the Membrane and Binding to Gα11". Mol. Cell. Biol. 19 (1): 714–23. PMC 83928. PMID 9858594. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=83928.
Dulin NO, Pratt P, Tiruppathi C et al. (2000). "Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis". J. Biol. Chem. 275 (28): 21317–23. doi:10.1074/jbc.M910079199. PMID 10749886.
Shi CS, Lee SB, Sinnarajah S et al. (2001). "Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation". J. Biol. Chem. 276 (26): 24293–300. doi:10.1074/jbc.M100089200. PMID 11294858.
Lu Q, Sun EE, Klein RS, Flanagan JG (2001). "Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction". Cell 105 (1): 69–79. doi:10.1016/S0092-8674(01)00297-5. PMID 11301003.
Mittmann C, Schüler C, Chung CH et al. (2001). "Evidence for a short form of RGS3 preferentially expressed in the human heart". Naunyn Schmiedebergs Arch. Pharmacol. 363 (4): 456–63. doi:10.1007/s002100000376. PMID 11330340.
Niu J, Scheschonka A, Druey KM et al. (2002). "RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain". Biochem. J. 365 (Pt 3): 677–84. doi:10.1042/BJ20020390. PMC 1222729. PMID 11985497. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222729.
Kehrl JH, Srikumar D, Harrison K et al. (2002). "Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3". Genomics 79 (6): 860–8. doi:10.1006/geno.2002.6773. PMID 12036301.
Ikeda M, Okai M, Miyoshi T et al. (2003). "Transcriptional suppression of the estrogen receptor by truncated estrogen receptor-alpha". Horm. Metab. Res. 34 (8): 425–30. doi:10.1055/s-2002-33599. PMID 12198596.
Hirabayashi S, Ohno H, Iida J, Hata Y (2003). "C2PA is a nuclear protein implicated in the heat shock response". J. Cell. Biochem. 87 (1): 65–74. doi:10.1002/jcb.10279. PMID 12210723.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081.
Tovey SC, Willars GB (2005). "Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor". Mol. Pharmacol. 66 (6): 1453–64. doi:10.1124/mol.104.005827. PMID 15383626.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

PDB gallery

2f5y: Crystal Structure of the PDZ Domain from Human RGS-3

2oj4: Crystal structure of RGS3 RGS domain

RGS3

References

Further reading