RGS12

Regulator of G-protein signaling 12

Identifiers

RGS12; DKFZp761K1617; DKFZp761K1817

External IDs

OMIM: 602512 MGI: 1918979 HomoloGene: 2195 GeneCards: RGS12 Gene

Gene Ontology
Molecular function	• receptor signaling protein activity • GTPase activator activity • GTPase regulator activity
Cellular component	• condensed nuclear chromosome • nucleus • cytoplasm • plasma membrane
Biological process	• regulation of G-protein coupled receptor protein signaling pathway • positive regulation of GTPase activity • positive regulation of GTPase activity • negative regulation of G-protein coupled receptor protein signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
3.29 – 3.44 Mb

Chr 5:
35.29 – 35.38 Mb

PubMed search

[1]

[2]

Regulator of G-protein signaling 12 is a protein that in humans is encoded by the RGS12 gene.^[1]^[2]

This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined.^[2]

Interactions

RGS12 has been shown to interact with GNAI1^[3] and GNAI3.^[3]

References

^ Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (Aug 1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". J Biol Chem 273 (28): 17749–55. doi:10.1074/jbc.273.28.17749. PMID 9651375.
^ ^a ^b "Entrez Gene: RGS12 regulator of G-protein signalling 12". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6002.
^ ^a ^b Kimple, R J; De Vries L, Tronchère H, Behe C I, Morris R A, Gist Farquhar M, Siderovski D P (Aug. 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". J. Biol. Chem. (United States) 276 (31): 29275–81. doi:10.1074/jbc.M103208200. ISSN 0021-9258. PMID 11387333.

Frohme M, Scharm B, Delius H, et al. (2000). "Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue.". Ann. N. Y. Acad. Sci. 910: 85–104; discussion 104–5. doi:10.1111/j.1749-6632.2000.tb06703.x. PMID 10911908.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Snow BE, Antonio L, Suggs S, et al. (1997). "Molecular cloning and expression analysis of rat Rgs12 and Rgs14.". Biochem. Biophys. Res. Commun. 233 (3): 770–7. doi:10.1006/bbrc.1997.6537. PMID 9168931.
Chatterjee TK, Fisher RA (2000). "Novel alternative splicing and nuclear localization of human RGS12 gene products.". J. Biol. Chem. 275 (38): 29660–71. doi:10.1074/jbc.M000330200. PMID 10869340.
Schiff ML, Siderovski DP, Jordan JD, et al. (2001). "Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel.". Nature 408 (6813): 723–7. doi:10.1038/35047093. PMID 11130074.
Kimple RJ, De Vries L, Tronchère H, et al. (2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.". J. Biol. Chem. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.
Snow BE, Brothers GM, Siderovski DP (2002). "Molecular cloning of regulators of G-protein signaling family members and characterization of binding specificity of RGS12 PDZ domain.". Meth. Enzymol. 344: 740–61. doi:10.1016/S0076-6879(02)44752-0. PMID 11771424.
Sierra DA, Gilbert DJ, Householder D, et al. (2002). "Evolution of the regulators of G-protein signaling multigene family in mouse and human.". Genomics 79 (2): 177–85. doi:10.1006/geno.2002.6693. PMID 11829488.
Chatterjee TK, Fisher RA (2002). "RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression.". Mol. Cell. Biol. 22 (12): 4334–45. doi:10.1128/MCB.22.12.4334-4345.2002. PMC 133853. PMID 12024043. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133853.
Potocnik U, Glavac D, Ravnik-Glavac M (2003). "Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability.". Genes Chromosomes Cancer 36 (1): 48–56. doi:10.1002/gcc.10141. PMID 12461749.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Yang S, Li YP (2007). "RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro.". J. Bone Miner. Res. 22 (1): 45–54. doi:10.1359/jbmr.061007. PMID 17042716.

RGS12

Interactions

References

Further reading