RGPD5

RANBP2-like and GRIP domain containing 5

PDB rendering based on 1xke.
Identifiers
Symbols RGPD5; BS-63; BS63; DKFZp686I1842; RGP5; RGPD6
External IDs OMIM: 612708 HomoloGene: 87808 GeneCards: RGPD5 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 84220 n/a
Ensembl ENSG00000153165 n/a
UniProt Q99666 n/a
RefSeq (mRNA) NM_005054.2 n/a
RefSeq (protein) NP_005045.2 n/a
Location (UCSC) Chr 2:
106.4 – 106.45 Mb		 n/a
PubMed search [1] n/a

RANBP2-like and GRIP domain-containing protein 5 is a protein that in humans is encoded by the RGPD5 gene.[1][2][3]

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined.[3]

Interactions

RGPD5 has been shown to interact with Transportin 1.[4]

References

  1. ^ Ciccarelli FD, von Mering C, Suyama M, Harrington ED, Izaurralde E, Bork P (Mar 2005). "Complex genomic rearrangements lead to novel primate gene function". Genome Res 15 (3): 343–51. doi:10.1101/gr.3266405. PMC 551560. PMID 15710750. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=551560. 
  2. ^ Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK (Apr 2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
  3. ^ a b "Entrez Gene: RGPD5 RANBP2-like and GRIP domain containing 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84220. 
  4. ^ Cai, Y; Miao S Y, Wang L F (Oct. 2001). "[Determination of the binding site of testis-specific nucleoporin BS-63 to transportin (karopherin beta 2) and the proof of their combination in vitro]". Zhongguo Yi Xue Ke Xue Yuan Xue Bao (China) 23 (5): 462–6. ISSN 1000-503X. PMID 12905863. 

Further reading