RGL2

Ral guanine nucleotide dissociation stimulator-like 2

PDB rendering based on 1rlf.

Available structures
PDB	1rlf

Identifiers

Symbols

RGL2; HKE1.5; KE1.5; RAB2L

External IDs

OMIM: 602306 MGI: 107483 HomoloGene: 3494 GeneCards: RGL2 Gene

Gene Ontology
Molecular function	• Ras guanyl-nucleotide exchange factor activity
Cellular component	• cellular_component • intracellular
Biological process	• signal transduction • Ras protein signal transduction • regulation of small GTPase mediated signal transduction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
33.37 – 33.38 Mb

Chr 17:
34.07 – 34.07 Mb

PubMed search

[1]

[2]

Ral guanine nucleotide dissociation stimulator-like 2 is a protein that in humans is encoded by the RGL2 gene.^[1]^[2]

Interactions

RGL2 has been shown to interact with HRAS.^[3]^[4]

References

^ Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y (Jan 1997). "Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS". Cytogenet Cell Genet 74 (4): 263–5. doi:10.1159/000134431. PMID 8976381.
^ "Entrez Gene: RGL2 ral guanine nucleotide dissociation stimulator-like 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5863.
^ Mitin, Natalia Y; Ramocki Melissa B, Zullo Alfred J, Der Channing J, Konieczny Stephen F, Taparowsky Elizabeth J (May. 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. (United States) 279 (21): 22353–61. doi:10.1074/jbc.M312867200. ISSN 0021-9258. PMID 15031288.
^ Peterson, S N; Trabalzini L, Brtva T R, Fischer T, Altschuler D L, Martelli P, Lapetina E G, Der C J, White G C (Nov. 1996). "Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1". J. Biol. Chem. (UNITED STATES) 271 (47): 29903–8. doi:10.1074/jbc.271.47.29903. ISSN 0021-9258. PMID 8939933.

Peterson SN, Trabalzini L, Brtva TR, et al. (1997). "Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1.". J. Biol. Chem. 271 (47): 29903–8. doi:10.1074/jbc.271.47.29903. PMID 8939933.
Herberg JA, Sgouros J, Jones T, et al. (1998). "Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC.". Eur. J. Immunol. 28 (2): 459–67. doi:10.1002/(SICI)1521-4141(199802)28:02<459::AID-IMMU459>3.0.CO;2-Z. PMID 9521053.
Herberg JA, Beck S, Trowsdale J (1998). "TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC.". J. Mol. Biol. 277 (4): 839–57. doi:10.1006/jmbi.1998.1637. PMID 9545376.
Ando A, Kikuti YY, Abe K, et al. (1999). "cDNA cloning, northern hybridization, and mapping analysis of a putative GDS-related protein gene at the centromeric ends of the human and mouse MHC regions.". Immunogenetics 49 (4): 354–6. doi:10.1007/s002510050504. PMID 10079301.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

PDB gallery

1rlf: STRUCTURE DETERMINATION OF THE RAS-BINDING DOMAIN OF THE RAL-SPECIFIC GUANINE NUCLEOTIDE EXCHANGE FACTOR RLF, NMR, 10 STRUCTURES

RGL2

Interactions

References

Further reading