RFT1

RFT1 homolog (S. cerevisiae)

Identifiers

RFT1; CDG1N; DKFZp667J092; FLJ25945

External IDs

OMIM: 611908 MGI: 3607791 HomoloGene: 5343 GeneCards: RFT1 Gene

Gene Ontology
Molecular function	• lipid transporter activity
Cellular component	• membrane • integral to membrane
Biological process	• dolichol-linked oligosaccharide biosynthetic process • transport • carbohydrate transport • protein N-linked glycosylation via asparagine • post-translational protein modification • cellular protein metabolic process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000163933

ENSMUSG00000052395

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
53.12 – 53.16 Mb

Chr 14:
31.47 – 31.5 Mb

PubMed search

Protein RFT1 homolog is a protein that in humans is encoded by the RFT1 gene.^[1]^[2]

Defects are associated with congenital disorder of glycosylation type 1N.^[2]

Contents

1 See also
2 References
3 Further reading
4 External links

See also

Flippase

References

^ "Entrez Gene: RFT1 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91869.
^ ^a ^b Haeuptle MA, Pujol FM, Neupert C, Winchester B, Kastaniotis AJ, Aebi M, Hennet T (March 2008). "Human RFT1 deficiency leads to a disorder of N-linked glycosylation". Am. J. Hum. Genet. 82 (3): 600–6. doi:10.1016/j.ajhg.2007.12.021. PMC 2427296. PMID 18313027. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2427296.

Further reading

Helenius J, Ng DT, Marolda CL, et al. (2002). "Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein.". Nature 415 (6870): 447–50. doi:10.1038/415447a. PMID 11807558.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Rose JE, Behm FM, Drgon T, et al.. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.". Mol. Med. 16 (7-8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2896464.

External links

GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview