RNA binding motif protein, Y-linked, family 1, member A1

RNA binding motif protein, Y-linked, family 1, member A1

PDB rendering based on 2fy1.
Identifiers
Symbols RBMY1A1; MGC181956; RBM; RBM1; RBM2; RBMY; RBMY1C; YRRM1; YRRM2
External IDs OMIM400006 HomoloGene121598 GeneCards: RBMY1A1 Gene
Orthologs
Species Human Mouse
Entrez 5940 n/a
Ensembl ENSG00000234414 n/a
UniProt Q15414 n/a
RefSeq (mRNA) NM_001007526 n/a
RefSeq (protein) NP_001007527 n/a
Location (UCSC) Chr Y:
23.67 – 23.71 Mb
n/a
PubMed search [1] n/a

RNA-binding motif protein, Y chromosome, family 1 member A1/C is a protein that in humans is encoded by the RBMY1A1 gene.[1][2][3]

This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. Alternative splicing of transcripts results in two transcript variants that encode different proteins.[3]

References

  1. ^ Ma K, Inglis JD, Sharkey A, Bickmore WA, Hill RE, Prosser EJ, Speed RM, Thomson EJ, Jobling M, Taylor K, et al. (Jan 1994). "A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis". Cell 75 (7): 1287–95. doi:10.1016/0092-8674(93)90616-X. PMID 8269511. 
  2. ^ Chai NN, Zhou H, Hernandez J, Najmabadi H, Bhasin S, Yen PH (Aug 1998). "Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene". Genomics 49 (2): 283–9. doi:10.1006/geno.1998.5255. PMID 9598316. 
  3. ^ a b "Entrez Gene: RBMY1A1 RNA binding motif protein, Y-linked, family 1, member A1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5940. 

Further reading