RBMX

RNA binding motif protein, X-linked

Identifiers

RBMX; HNRPG; RBMXP1; RBMXRT; RNMX; hnRNP-G

External IDs

OMIM: 300199 MGI: 1343044 HomoloGene: 20494 GeneCards: RBMX Gene

Gene Ontology
Molecular function	• nucleotide binding • RNA binding • protein binding
Cellular component	• nucleus • nucleoplasm • heterogeneous nuclear ribonucleoprotein complex • catalytic step 2 spliceosome
Biological process	• nuclear mRNA splicing, via spliceosome • nuclear mRNA splicing, via spliceosome • RNA splicing • gene expression
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
135.95 – 135.96 Mb

Chr X:
54.64 – 54.65 Mb

PubMed search

[1]

[2]

Heterogeneous nuclear ribonucleoprotein G is a protein that in humans is encoded by the RBMX gene.^[1]^[2]^[3]

This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified but their biological nature has not been determined.^[3]

Interactions

RBMX has been shown to interact with SFRS10^[4] and CDC5L.^[5]

References

^ Delbridge ML, Lingenfelter PA, Disteche CM, Graves JA (Jul 1999). "The candidate spermatogenesis gene RBMY has a homologue on the human X chromosome". Nat Genet 22 (3): 223–224. doi:10.1038/10279. PMID 10391206.
^ Mazeyrat S, Saut N, Mattei MG, Mitchell MJ (Jul 1999). "RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene". Nat Genet 22 (3): 224–226. doi:10.1038/10282. PMID 10391207.
^ ^a ^b "Entrez Gene: RBMX RNA binding motif protein, X-linked". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27316.
^ Hofmann, Yvonne; Wirth Brunhilde (Aug. 2002). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Hum. Mol. Genet. (England) 11 (17): 2037–2049. doi:10.1093/hmg/11.17.2037. ISSN 0964-6906. PMID 12165565.
^ Ajuh, P; Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I (Dec. 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–6581. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305846.

Le Coniat M, Soulard M, Della Valle V et al. (1992). "Localization of the human gene encoding heterogeneous nuclear RNA ribonucleoprotein G (hnRNP-G) to chromosome 6p12". Hum. Genet. 88 (5): 593–5. PMID 1551662.
Soulard M, Della Valle V, Siomi MC et al. (1993). "hnRNP G: sequence and characterization of a glycosylated RNA-binding protein". Nucleic Acids Res. 21 (18): 4210–4217. doi:10.1093/nar/21.18.4210. PMC 310052. PMID 7692398. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310052.
Hillier LD, Lennon G, Becker M et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–828. doi:10.1101/gr.6.9.807. PMID 8889549.
Venables JP, Vernet C, Chew SL et al. (1999). "T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis". Hum. Mol. Genet. 8 (6): 959–969. doi:10.1093/hmg/8.6.959. PMID 10332027.
Venables JP, Elliott DJ, Makarova OV et al. (2000). "RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing". Hum. Mol. Genet. 9 (5): 685–694. doi:10.1093/hmg/9.5.685. PMID 10749975.
Ajuh P, Kuster B, Panov K et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–6581. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305846.
Lingenfelter PA, Delbridge ML, Thomas S et al. (2001). "Expression and conservation of processed copies of the RBMX gene". Mamm. Genome 12 (7): 538–545. doi:10.1007/s00335001-0003-z. PMID 11420617.
Jurica MS, Licklider LJ, Gygi SR et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–439. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370266.
Hofmann Y, Wirth B (2003). "hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1". Hum. Mol. Genet. 11 (17): 2037–2049. doi:10.1093/hmg/11.17.2037. PMID 12165565.
Angenstein F, Evans AM, Settlage RE et al. (2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". J. Neurosci. 22 (20): 8827–37. PMID 12388589.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Li J, Hawkins IC, Harvey CD et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–7447. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=207616.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–2772. doi:10.1021/ac035352d. PMID 15144186.
Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Ross MT, Grafham DV, Coffey AJ et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–337. doi:10.1038/nature03440. PMC 2665286. PMID 15772651. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665286.
Ong SE, Mittler G, Mann M (2005). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nat. Methods 1 (2): 119–126. doi:10.1038/nmeth715. PMID 15782174.

RBMX

Interactions

References

Further reading