RBMS1
RNA-binding motif, single-stranded-interacting protein 1 is a protein that in humans is encoded by the RBMS1 gene.[1][2][3][4]
This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Multiple transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. Several of these were isolated by virtue of their binding to either strand of an upstream element of c-myc (MSSPs), or by phenotypic complementation of cdc2 and cdc13 mutants of yeast (scr2), or as a potential human repressor of HIV-1 and ILR-2 alpha promoter transcription (YC1). A pseudogene for this locus is found on chromosome 12.[4]
Interactions
RBMS1 has been shown to interact with Polymerase (DNA directed), alpha 1.[5]
References
- ^ Kanaoka Y, Nojima H (Aug 1994). "SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins". Nucleic Acids Res 22 (13): 2687–93. doi:10.1093/nar/22.13.2687. PMC 308228. PMID 8041632. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=308228.
- ^ Negishi Y, Nishita Y, Saegusa Y, Kakizaki I, Galli I, Kihara F, Tamai K, Miyajima N, Iguchi-Ariga SM, Ariga H (Apr 1994). "Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene". Oncogene 9 (4): 1133–43. PMID 8134115.
- ^ Takai T, Nishita Y, Iguchi-Ariga SM, Ariga H (Feb 1995). "Molecular cloning of MSSP-2, a c-myc gene single-strand binding protein: characterization of binding specificity and DNA replication activity". Nucleic Acids Res 22 (25): 5576–81. doi:10.1093/nar/22.25.5576. PMC 310119. PMID 7838710. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310119.
- ^ a b "Entrez Gene: RBMS1 RNA binding motif, single stranded interacting protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5937.
- ^ Niki, T; Galli I, Ariga H, Iguchi-Ariga S M (Jun. 2000). "MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity". FEBS Lett. (NETHERLANDS) 475 (3): 209–12. doi:10.1016/S0014-5793(00)01679-3. ISSN 0014-5793. PMID 10869558.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Haigermoser C, Fujimoto M, Iguchi-Ariga SM, Ariga H (1996). "Cloning and characterization of the genomic DNA of the human MSSP genes.". Nucleic Acids Res. 24 (19): 3846–57. doi:10.1093/nar/24.19.3846. PMC 146151. PMID 8871567. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=146151.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Niki T, Galli I, Ariga H, Iguchi-Ariga SM (2000). "MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity.". FEBS Lett. 475 (3): 209–12. doi:10.1016/S0014-5793(00)01679-3. PMID 10869558.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
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PDB gallery
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1x4e: Solution structure of RRM domain in RNA binding motif, single-stranded interacting protein 2
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1x5o: Solution structure of RRM domain in RNA binding motif, single-stranded interacting protein 1
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