RASSF5

Ras association (RalGDS/AF-6) domain family member 5

PDB rendering based on 2fnf.

Available structures
PDB	2fnf

Identifiers

Symbols

RASSF5; MGC10823; MGC17344; Maxp1; NORE1; NORE1A; NORE1B; RAPL; RASSF3

External IDs

OMIM: 607020 MGI: 1926375 HomoloGene: 10296 GeneCards: RASSF5 Gene

Gene Ontology
Molecular function	• protein binding • identical protein binding • metal ion binding
Cellular component	• cytoplasm • cytoskeleton • microtubule
Biological process	• apoptosis • intracellular signal transduction
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
206.68 – 206.76 Mb

Chr 1:
133.07 – 133.14 Mb

PubMed search

[1]

[2]

Ras association domain-containing protein 5 is a protein that in humans is encoded by the RASSF5 or F5 gene.^[1]^[2]^[3]

This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.^[3]

Interactions

RASSF5 has been shown to interact with RRAS,^[4] RAP2A,^[4] MRAS^[4] and RASSF1.^[4]

References

^ Yao R, Wang Y, You M (Apr 2002). "Chromosome mapping and sequence variation of the murine Ras effector gene Nore1". Cytogenet Cell Genet 95 (1–2): 126–8. doi:10.1159/000057035. PMID 11978988.
^ Tommasi S, Dammann R, Jin SG, Zhang XF, Avruch J, Pfeifer GP (Apr 2002). "RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1". Oncogene 21 (17): 2713–20. doi:10.1038/sj.onc.1205365. PMID 11965544.
^ ^a ^b "Entrez Gene: RASSF5 Ras association (RalGDS/AF-6) domain family 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83593.
^ ^a ^b ^c ^d Ortiz-Vega, Sara; Khokhlatchev Andrei, Nedwidek Maria, Zhang Xian-feng, Dammann Reinhard, Pfeifer Gerd P, Avruch Joseph (Feb. 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene (England) 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. ISSN 0950-9232. PMID 11857081.

Kumari G, Singhal PK, Suryaraja R, Mahalingam S. (2010). "Functional interaction of the Ras effector RASSF5 with the tyrosine kinase Lck: critical role in nucleocytoplasmic transport and cell cycle regulation". J Mol Biol. 397 (1): 89–109. doi:10.1016/j.jmb.2010.01.005. PMID 20064523.
Vavvas D, Li X, Avruch J, Zhang XF (1998). "Identification of Nore1 as a potential Ras effector". J. Biol. Chem. 273 (10): 5439–42. doi:10.1074/jbc.273.10.5439. PMID 9488663.
Ortiz-Vega S, Khokhlatchev A, Nedwidek M et al. (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
Khokhlatchev A, Rabizadeh S, Xavier R et al. (2002). "Identification of a novel Ras-regulated proapoptotic pathway". Curr. Biol. 12 (4): 253–65. doi:10.1016/S0960-9822(02)00683-8. PMID 11864565.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Vos MD, Martinez A, Ellis CA et al. (2003). "The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lung". J. Biol. Chem. 278 (24): 21938–43. doi:10.1074/jbc.M211019200. PMID 12676952.
Katagiri K, Maeda A, Shimonaka M, Kinashi T (2003). "RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1". Nat. Immunol. 4 (8): 741–8. doi:10.1038/ni950. PMID 12845325.
Chen J, Lui WO, Vos MD et al. (2004). "The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomas". Cancer Cell 4 (5): 405–13. doi:10.1016/S1535-6108(03)00269-1. PMID 14667507.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J (2004). "Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras". Biochem. J. 381 (Pt 2): 453–62. doi:10.1042/BJ20040025. PMC 1133852. PMID 15109305. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1133852.
Irimia M, Fraga MF, Sanchez-Cespedes M, Esteller M (2004). "CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer". Oncogene 23 (53): 8695–9. doi:10.1038/sj.onc.1207914. PMID 15378027.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Fujita H, Fukuhara S, Sakurai A et al. (2005). "Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes". J. Biol. Chem. 280 (6): 5022–31. doi:10.1074/jbc.M409701200. PMID 15569673.
Nakamura N, Carney JA, Jin L et al. (2005). "RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors". Lab. Invest. 85 (9): 1065–75. doi:10.1038/labinvest.3700306. PMID 15980887.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Foukakis T, Au AY, Wallin G et al. (2006). "The Ras effector NORE1A is suppressed in follicular thyroid carcinomas with a PAX8-PPARgamma fusion". J. Clin. Endocrinol. Metab. 91 (3): 1143–9. doi:10.1210/jc.2005-1372. PMID 16352687.
Moshnikova A, Frye J, Shay JW et al. (2006). "The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway". J. Biol. Chem. 281 (12): 8143–52. doi:10.1074/jbc.M511837200. PMID 16421102.
Macheiner D, Heller G, Kappel S et al. (2006). "NORE1B, a candidate tumor suppressor, is epigenetically silenced in human hepatocellular carcinoma". J. Hepatol. 45 (1): 81–9. doi:10.1016/j.jhep.2005.12.017. PMID 16516329.
Ishiguro K, Avruch J, Landry A et al. (2006). "Nore1B regulates TCR signaling via Ras and Carma1". Cell. Signal. 18 (10): 1647–54. doi:10.1016/j.cellsig.2006.01.015. PMID 16520020.

PDB gallery

2fnf: C1 domain of Nore1

RASSF5

Interactions

References

Further reading