RASSF1

Ras association (RalGDS/AF-6) domain family member 1
Identifiers
Symbols RASSF1; 123F2; NORE2A; RASSF1A; RDA32; REH3P21
External IDs OMIM: 605082 HomoloGene: 10499 GeneCards: RASSF1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 11186 n/a
Ensembl ENSG00000068028 n/a
UniProt Q9NS23 n/a
RefSeq (mRNA) NM_001206957.1 n/a
RefSeq (protein) NP_001193886.1 n/a
Location (UCSC) Chr 3:
50.37 – 50.38 Mb		 n/a
PubMed search [1] n/a

Ras association domain-containing protein 1 is a protein that in humans is encoded by the RASSF1 gene.

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[1]

Interactions

RASSF1 has been shown to interact with MAP1B,[2] RASSF5,[3] CNKSR1,[4] HRAS,[5] Death associated protein 6[6] and MAP1S.[7][2]

References

  1. ^ "Entrez Gene: RASSF1 Ras association (RalGDS/AF-6) domain family 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11186. 
  2. ^ a b Dallol, Ashraf; Agathanggelou Angelo, Fenton Sarah L, Ahmed-Choudhury Jalal, Hesson Luke, Vos Michele D, Clark Geoffrey J, Downward Julian, Maher Eamonn R, Latif Farida (Jun. 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. (United States) 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. ISSN 0008-5472. PMID 15205320. 
  3. ^ Ortiz-Vega, Sara; Khokhlatchev Andrei, Nedwidek Maria, Zhang Xian-feng, Dammann Reinhard, Pfeifer Gerd P, Avruch Joseph (Feb. 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene (England) 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. ISSN 0950-9232. PMID 11857081. 
  4. ^ Rabizadeh, Shahrooz; Xavier Ramnik J, Ishiguro Kazuhiro, Bernabeortiz Juliocesar, Lopez-Ilasaca Marco, Khokhlatchev Andrei, Mollahan Pamela, Pfeifer Gerd P, Avruch Joseph, Seed Brian (Jul. 2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. (United States) 279 (28): 29247–54. doi:10.1074/jbc.M401699200. ISSN 0021-9258. PMID 15075335. 
  5. ^ Vos, M D; Ellis C A, Bell A, Birrer M J, Clark G J (Nov. 2000). "Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis". J. Biol. Chem. (UNITED STATES) 275 (46): 35669–72. doi:10.1074/jbc.C000463200. ISSN 0021-9258. PMID 10998413. 
  6. ^ Song, Min Sup; Song Su Jung, Kim So Yeon, Oh Hyun Jung, Lim Dae-Sik (Jul. 2008). "The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex". EMBO J. (England) 27 (13): 1863–74. doi:10.1038/emboj.2008.115. PMC 2486425. PMID 18566590. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2486425. 
  7. ^ Liu, Leyuan; Vo Amy, McKeehan Wallace L (Mar. 2005). "Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5". Cancer Res. (United States) 65 (5): 1830–8. doi:10.1158/0008-5472.CAN-04-3896. ISSN 0008-5472. PMID 15753381.