RASGRP3

RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Identifiers
Symbols RASGRP3; GRP3; KIAA0846
External IDs OMIM609531 MGI3028579 HomoloGene15019 GeneCards: RASGRP3 Gene
Orthologs
Species Human Mouse
Entrez 25780 240168
Ensembl ENSG00000152689 ENSMUSG00000071042
UniProt Q8IV61 n/a
RefSeq (mRNA) NM_001139488.1 NM_207246
RefSeq (protein) NP_001132960.1 NP_997129
Location (UCSC) Chr 2:
33.66 – 33.79 Mb
Chr 17:
75.84 – 75.93 Mb
PubMed search [1] [2]

Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene.[1][2][3]

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM][3]

Interactions

RASGRP3 has been shown to interact with PRKCD.[4]

References

  1. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485. 
  2. ^ Rebhun JF, Castro AF, Quilliam LA (Nov 2000). "Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction". J Biol Chem 275 (45): 34901–8. doi:10.1074/jbc.M005327200. PMID 10934204. 
  3. ^ a b "Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25780. 
  4. ^ Brodie, Chaya; Steinhart Rivka, Kazimirsky Gila, Rubinfeld Hadara, Hyman Tehila, Ayres Jolene N, Hur Gang Min, Toth Attila, Yang Dazhi, Garfield Susan H, Stone James C, Blumberg Peter M (Jul. 2004). "PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters". Mol. Pharmacol. (United States) 66 (1): 76–84. doi:10.1124/mol.66.1.76. ISSN 0026-895X. PMID 15213298. 

Further reading