RAPGEF5

Rap guanine nucleotide exchange factor (GEF) 5

PDB rendering based on 1wgy.
Identifiers
Symbols RAPGEF5; GFR; KIAA0277; MR-GEF; REPAC
External IDs OMIM: 609527 MGI: 2444365 HomoloGene: 56563 GeneCards: RAPGEF5 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 9771 217944
Ensembl ENSG00000136237 ENSMUSG00000041992
UniProt Q92565 Q3TS77
RefSeq (mRNA) XM_928602 NM_175930.5
RefSeq (protein) XP_933695 NP_787126.3
Location (UCSC) Chr 7:
22.16 – 22.4 Mb		 Chr 12:
118.75 – 119 Mb
PubMed search [1] [2]

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.[1][2][3]

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM][3]

References

  1. ^ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502. 
  2. ^ Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y (Oct 1999). "Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1". FEBS Lett 457 (1): 85–9. doi:10.1016/S0014-5793(99)01012-1. PMID 10486569. 
  3. ^ a b "Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9771. 

Further reading