RALB

V-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)

Rendering based on PDB 2KE5.

Available structures
PDB	2KE5, 2KWI

Identifiers

Symbols

RALB;

External IDs

OMIM: 179551 MGI: 1927244 HomoloGene: 20632 GeneCards: RALB Gene

Gene Ontology
Molecular function	• nucleotide binding • GTPase activity • protein binding • GTP binding
Cellular component	• intracellular • cytosol • plasma membrane • midbody
Biological process	• cytokinesis • regulation of exocyst assembly • GTP catabolic process • apoptosis • cell cycle • signal transduction • Ras protein signal transduction • nerve growth factor receptor signaling pathway • regulation of exocyst localization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
121 – 121.05 Mb

Chr 1:
121.37 – 121.4 Mb

PubMed search

[1]

[2]

Ras-related protein Ral-B is a protein that in humans is encoded by the RALB gene.^[1]

This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors.^[1]

Interactions

RALB has been shown to interact with EXOC8^[2] and RALBP1.^[2]^[3]^[4]

References

^ ^a ^b "Entrez Gene: RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5899.
^ ^a ^b Moskalenko, Serge; Tong Chao, Rosse Carine, Mirey Gladys, Formstecher Etienne, Daviet Laurent, Camonis Jacques, White Michael A (Dec. 2003). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. (United States) 278 (51): 51743–8. doi:10.1074/jbc.M308702200. ISSN 0021-9258. PMID 14525976.
^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
^ Jullien-Flores, V; Dorseuil O, Romero F, Letourneur F, Saragosti S, Berger R, Tavitian A, Gacon G, Camonis J H (Sep. 1995). "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". J. Biol. Chem. (UNITED STATES) 270 (38): 22473–7. doi:10.1074/jbc.270.38.22473. ISSN 0021-9258. PMID 7673236.

Hsieh CL, Swaroop A, Francke U (1990). "Chromosomal localization and cDNA sequence of human ralB, a GTP binding protein.". Somat. Cell Mol. Genet. 16 (4): 407–10. doi:10.1007/BF01232469. PMID 2120779.
Chardin P, Tavitian A (1989). "Coding sequences of human ralA and ralB cDNAs". Nucleic Acids Res. 17 (11): 4380. doi:10.1093/nar/17.11.4380. PMC 317954. PMID 2662142. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=317954.
Jullien-Flores V, Dorseuil O, Romero F, et al. (1995). "Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity". J. Biol. Chem. 270 (38): 22473–7. doi:10.1074/jbc.270.38.22473. PMID 7673236.
Jilkina O, Bhullar RP (1997). "Generation of antibodies specific for the RalA and RalB GTP-binding proteins and determination of their concentration and distribution in human platelets". Biochim. Biophys. Acta 1314 (1–2): 157–66. PMID 8972729.
Ikeda M, Ishida O, Hinoi T, et al. (1998). "Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral". J. Biol. Chem. 273 (2): 814–21. doi:10.1074/jbc.273.2.814. PMID 9422736.
Sugihara K, Asano S, Tanaka K, et al. (2002). "The exocyst complex binds the small GTPase RalA to mediate filopodia formation". Nat. Cell Biol. 4 (1): 73–8. doi:10.1038/ncb720. PMID 11744922.
Clough RR, Sidhu RS, Bhullar RP (2002). "Calmodulin binds RalA and RalB and is required for the thrombin-induced activation of Ral in human platelets". J. Biol. Chem. 277 (32): 28972–80. doi:10.1074/jbc.M201504200. PMID 12034722.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Chien Y, White MA (2004). "RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival". EMBO Rep. 4 (8): 800–6. doi:10.1038/sj.embor.embor899. PMC 1326339. PMID 12856001. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1326339.
Hernández-Muñoz I, Benet M, Calero M, et al. (2003). "rgr oncogene: activation by elimination of translational controls and mislocalization". Cancer Res. 63 (14): 4188–95. PMID 12874025.
Moskalenko S, Tong C, Rosse C, et al. (2004). "Ral GTPases regulate exocyst assembly through dual subunit interactions". J. Biol. Chem. 278 (51): 51743–8. doi:10.1074/jbc.M308702200. PMID 14525976.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Sidhu RS, Clough RR, Bhullar RP (2005). "Regulation of phospholipase C-delta1 through direct interactions with the small GTPase Ral and calmodulin". J. Biol. Chem. 280 (23): 21933–41. doi:10.1074/jbc.M412966200. PMID 15817490.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Chien Y, Kim S, Bumeister R, et al. (2006). "RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival". Cell 127 (1): 157–70. doi:10.1016/j.cell.2006.08.034. PMID 17018283.
Lim KH, O'Hayer K, Adam SJ, et al. (2007). "Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells". Curr. Biol. 16 (24): 2385–94. doi:10.1016/j.cub.2006.10.023. PMID 17174914.
Smith SC, Oxford G, Baras AS, et al. (2007). "Expression of ral GTPases, their effectors, and activators in human bladder cancer". Clin. Cancer Res. 13 (13): 3803–13. doi:10.1158/1078-0432.CCR-06-2419. PMID 17606711.
Yin J, Pollock C, Tracy K, et al. (2007). "Activation of the RalGEF/Ral Pathway Promotes Prostate Cancer Metastasis to Bone". Mol. Cell. Biol. 27 (21): 7538–50. doi:10.1128/MCB.00955-07. PMC 2169046. PMID 17709381. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2169046.

RALB

Interactions

References

Further reading