RAD54B

RAD54 homolog B (S. cerevisiae)
Identifiers
Symbols RAD54B; FSBP; RDH54
External IDs OMIM604289 MGI2444973 HomoloGene88020 GeneCards: RAD54B Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 25788 623474
Ensembl ENSG00000197275 ENSMUSG00000066307
UniProt Q9Y620 Q6PFE3
RefSeq (mRNA) NM_001205262.1 NM_001039556
RefSeq (protein) NP_001192191.1 NP_001034645
Location (UCSC) Chr 8:
95.38 – 95.49 Mb
Chr 4:
11.49 – 11.54 Mb
PubMed search [1] [2]

DNA repair and recombination protein RAD54B is a protein that in humans is encoded by the RAD54B gene.[1][2][3]

The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer.[3]

Interactions

RAD54B has been shown to interact with RAD51.[2]

References

  1. ^ Hiramoto T, Nakanishi T, Sumiyoshi T, Fukuda T, Matsuura S, Tauchi H, Komatsu K, Shibasaki Y, Inui H, Watatani M, Yasutomi M, Sumii K, Kajiyama G, Kamada N, Miyagawa K, Kamiya K (Jun 1999). "Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer". Oncogene 18 (22): 3422–6. doi:10.1038/sj.onc.1202691. PMID 10362364. 
  2. ^ a b Tanaka K, Hiramoto T, Fukuda T, Miyagawa K (Sep 2000). "A novel human rad54 homologue, Rad54B, associates with Rad51". J Biol Chem 275 (34): 26316–21. doi:10.1074/jbc.M910306199. PMID 10851248. 
  3. ^ a b "Entrez Gene: RAD54B RAD54 homolog B (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25788. 

Further reading