RAD51L3

RAD51-like 3 (S. cerevisiae)
Identifiers
Symbols RAD51L3; R51H3; RAD51D; TRAD
External IDs OMIM: 602954 MGI: 1261809 HomoloGene: 2156 GeneCards: RAD51L3 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5892 19364
Ensembl ENSG00000185379 ENSMUSG00000018841
UniProt O75771 Q5SU85
RefSeq (mRNA) NM_001142571.1 NM_011235.3
RefSeq (protein) NP_001136043.1 NP_035365.1
Location (UCSC) Chr 17:
33.43 – 33.45 Mb		 Chr 11:
82.69 – 82.7 Mb
PubMed search [1] [2]

DNA repair protein RAD51 homolog 4 is a protein that in humans is encoded by the RAD51L3 gene.[1][2]

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Several alternatively spliced transcript variants of this gene have been described, but the biological validity of some of them has not been determined.[2]

Interactions

RAD51L3 has been shown to interact with XRCC2,[3][4][5][6] Bloom syndrome protein[4] and RAD51C.[7][6]

References

  1. ^ Pittman DL, Weinberg LR, Schimenti JC (Jun 1998). "Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene". Genomics 49 (1): 103–11. doi:10.1006/geno.1998.5226. PMID 9570954. 
  2. ^ a b "Entrez Gene: RAD51L3 RAD51-like 3 (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5892. 
  3. ^ Schild, D; Lio Y C, Collins D W, Tsomondo T, Chen D J (Jun. 2000). "Evidence for simultaneous protein interactions between human Rad51 paralogs". J. Biol. Chem. (UNITED STATES) 275 (22): 16443–9. doi:10.1074/jbc.M001473200. ISSN 0021-9258. PMID 10749867. 
  4. ^ a b Braybrooke, Jeremy P; Li Ji-Liang, Wu Leonard, Caple Fiona, Benson Fiona E, Hickson Ian D (Nov. 2003). "Functional interaction between the Bloom's syndrome helicase and the RAD51 paralog, RAD51L3 (RAD51D)". J. Biol. Chem. (United States) 278 (48): 48357–66. doi:10.1074/jbc.M308838200. ISSN 0021-9258. PMID 12975363. 
  5. ^ Hussain, Shobbir; Wilson James B, Medhurst Annette L, Hejna James, Witt Emily, Ananth Sahana, Davies Adelina, Masson Jean-Yves, Moses Robb, West Stephen C, de Winter Johan P, Ashworth Alan, Jones Nigel J, Mathew Christopher G (Jun. 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. (England) 13 (12): 1241–8. doi:10.1093/hmg/ddh135. ISSN 0964-6906. PMID 15115758. 
  6. ^ a b Liu, Nan; Schild David, Thelen Michael P, Thompson Larry H (Feb. 2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells". Nucleic Acids Res. (England) 30 (4): 1009–15. doi:10.1093/nar/30.4.1009. PMC 100342. PMID 11842113. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=100342. 
  7. ^ Miller, Kristi A; Yoshikawa Daniel M, McConnell Ian R, Clark Robin, Schild David, Albala Joanna S (Mar. 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. (United States) 277 (10): 8406–11. doi:10.1074/jbc.M108306200. ISSN 0021-9258. PMID 11744692. 

Further reading