RAD51L1

RAD51-like 1 (S. cerevisiae)

Identifiers

RAD51L1; MGC34245; R51H2; RAD51B; REC2; hREC2

External IDs

OMIM: 602948 MGI: 1099436 HomoloGene: 50190 GeneCards: RAD51L1 Gene

Gene Ontology
Molecular function	• nucleotide binding • DNA binding • ATP binding • DNA-dependent ATPase activity • nucleoside-triphosphatase activity
Cellular component	• nucleus • nucleoplasm • nucleoplasm
Biological process	• DNA repair • DNA recombination • reciprocal meiotic recombination • blood coagulation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 14:
68.29 – 69.2 Mb

Chr 12:
80.4 – 80.9 Mb

PubMed search

[1]

[2]

DNA repair protein RAD51 homolog 2 is a protein that in humans is encoded by the RAD51L1 gene.^[1]^[2]^[3]

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed.^[3]

Interactions

RAD51L1 has been shown to interact with RAD51C.^[4]^[5]^[6]

References

^ Rapp UR, Marshall TH (Jun 1981). "Cell surface receptors for endogenous mouse type C viral glycoproteins and epidermal growth factor: tissue distribution in vivo and possible participation in specific cell-cell interaction". J Supramol Struct 14 (3): 343–52. doi:10.1002/jss.400140308. PMID 6261043.
^ Rice MC, Smith ST, Bullrich F, Havre P, Kmiec EB (Aug 1997). "Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis". Proc Natl Acad Sci U S A 94 (14): 7417–22. doi:10.1073/pnas.94.14.7417. PMC 23836. PMID 9207106. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=23836.
^ ^a ^b "Entrez Gene: RAD51L1 RAD51-like 1 (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5890.
^ Hussain, Shobbir; Wilson James B, Medhurst Annette L, Hejna James, Witt Emily, Ananth Sahana, Davies Adelina, Masson Jean-Yves, Moses Robb, West Stephen C, de Winter Johan P, Ashworth Alan, Jones Nigel J, Mathew Christopher G (Jun. 2004). "Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways". Hum. Mol. Genet. (England) 13 (12): 1241–8. doi:10.1093/hmg/ddh135. ISSN 0964-6906. PMID 15115758.
^ Sigurdsson, S; Van Komen S, Bussen W, Schild D, Albala J S, Sung P (Dec. 2001). "Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange". Genes Dev. (United States) 15 (24): 3308–18. doi:10.1101/gad.935501. ISSN 0890-9369. PMC 312844. PMID 11751636. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=312844.
^ Miller, Kristi A; Yoshikawa Daniel M, McConnell Ian R, Clark Robin, Schild David, Albala Joanna S (Mar. 2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51". J. Biol. Chem. (United States) 277 (10): 8406–11. doi:10.1074/jbc.M108306200. ISSN 0021-9258. PMID 11744692.

Dreikorn K, Röhl L (1974). "Preservation and transplantation of human cadaver kidneys. Experiences with the Gamgro perfusion unit.". Scand. J. Urol. Nephrol. 8 (1): 19–26. doi:10.3109/00365597409132812. PMID 4595808.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Albala JS, Thelen MP, Prange C, et al. (1998). "Identification of a novel human RAD51 homolog, RAD51B.". Genomics 46 (3): 476–9. doi:10.1006/geno.1997.5062. PMID 9441753.
Cartwright R, Dunn AM, Simpson PJ, et al. (1998). "Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family.". Nucleic Acids Res. 26 (7): 1653–9. doi:10.1093/nar/26.7.1653. PMC 147465. PMID 9512535. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=147465.
Havre PA, Rice MC, Noe M, Kmiec EB (1998). "The human REC2/RAD51B gene acts as a DNA damage sensor by inducing G1 delay and hypersensitivity to ultraviolet irradiation.". Cancer Res. 58 (20): 4733–9. PMID 9788630.
Peng L, Rice MC, Kmiec EB (1999). "Analysis of the human RAD51L1 promoter region and its activation by UV light.". Genomics 54 (3): 529–41. doi:10.1006/geno.1998.5536. PMID 9878257.
Schoenmakers EF, Huysmans C, Van de Ven WJ (1999). "Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas.". Cancer Res. 59 (1): 19–23. PMID 9892177.
Ingraham SE, Lynch RA, Kathiresan S, et al. (1999). "hREC2, a RAD51-like gene, is disrupted by t(12;14) (q15;q24.1) in a uterine leiomyoma.". Cancer Genet. Cytogenet. 115 (1): 56–61. doi:10.1016/S0165-4608(99)00070-9. PMID 10565301.
Takata M, Sasaki MS, Sonoda E, et al. (2000). "The Rad51 paralog Rad51B promotes homologous recombinational repair.". Mol. Cell. Biol. 20 (17): 6476–82. doi:10.1128/MCB.20.17.6476-6482.2000. PMC 86122. PMID 10938124. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86122.
Miller KA, Yoshikawa DM, McConnell IR, et al. (2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51.". J. Biol. Chem. 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.
Masson JY, Tarsounas MC, Stasiak AZ, et al. (2002). "Identification and purification of two distinct complexes containing the five RAD51 paralogs.". Genes Dev. 15 (24): 3296–307. doi:10.1101/gad.947001. PMC 312846. PMID 11751635. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=312846.
Sigurdsson S, Van Komen S, Bussen W, et al. (2002). "Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange.". Genes Dev. 15 (24): 3308–18. doi:10.1101/gad.935501. PMC 312844. PMID 11751636. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=312844.
Wiese C, Collins DW, Albala JS, et al. (2002). "Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells.". Nucleic Acids Res. 30 (4): 1001–8. doi:10.1093/nar/30.4.1001. PMC 100332. PMID 11842112. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=100332.
Liu N, Schild D, Thelen MP, Thompson LH (2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.". Nucleic Acids Res. 30 (4): 1009–15. doi:10.1093/nar/30.4.1009. PMC 100342. PMID 11842113. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=100342.
Blank C, Schoenmakers EF, Rogalla P, et al. (2002). "Intragenic breakpoint within RAD51L1 in a t(6;14)(p21.3;q24) of a pulmonary chondroid hamartoma.". Cytogenet. Cell Genet. 95 (1-2): 17–9. doi:10.1159/000057011. PMID 11978964.
Godthelp BC, Artwert F, Joenje H, Zdzienicka MZ (2002). "Impaired DNA damage-induced nuclear Rad51 foci formation uniquely characterizes Fanconi anemia group D1.". Oncogene 21 (32): 5002–5. doi:10.1038/sj.onc.1205656. PMID 12118380.
Lio YC, Mazin AV, Kowalczykowski SC, Chen DJ (2003). "Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro.". J. Biol. Chem. 278 (4): 2469–78. doi:10.1074/jbc.M211038200. PMID 12427746.
Yokoyama H, Kurumizaka H, Ikawa S, et al. (2003). "Holliday junction binding activity of the human Rad51B protein.". J. Biol. Chem. 278 (4): 2767–72. doi:10.1074/jbc.M210899200. PMID 12441335.

RAD51L1

Interactions

References

Further reading