RAB9A

RAB9A, member RAS oncogene family

PDB rendering based on 1s8f.

Available structures
PDB	1s8f, 1wms, 1yzl

Identifiers

RAB9A; RAB9

External IDs

OMIM: 300284 MGI: 1890695 HomoloGene: 20900 GeneCards: RAB9A Gene

Gene Ontology
Molecular function	• nucleotide binding • GTPase activity • protein binding • GTP binding • GDP binding
Cellular component	• Golgi membrane • lysosome • late endosome • endoplasmic reticulum • endoplasmic reticulum membrane • Golgi apparatus • plasma membrane
Biological process	• GTP catabolic process • GTP catabolic process • small GTPase mediated signal transduction • protein transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000123595

ENSMUSG00000079316

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
13.71 – 13.73 Mb

Chr X:
162.9 – 162.92 Mb

PubMed search

Ras-related protein Rab-9A is a protein that in humans is encoded by the RAB9A gene.^[1]^[2]

Interactions

RAB9A has been shown to interact with RABEPK^[3] and TIP47.^[4]

References

^ Davies JP, Cotter PD, Ioannou YA (May 1997). "Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene". Genomics 41 (1): 131–4. doi:10.1006/geno.1997.4644. PMID 9126495.
^ "Entrez Gene: RAB9A RAB9A, member RAS oncogene family". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9367.
^ Díaz, E; Schimmöller F, Pfeffer S R (Jul. 1997). "A novel Rab9 effector required for endosome-to-TGN transport". J. Cell Biol. (UNITED STATES) 138 (2): 283–90. doi:10.1083/jcb.138.2.283. ISSN 0021-9525. PMC 2138197. PMID 9230071. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2138197.
^ Carroll, KS; Hanna J, Simon I, Krise J, Barbero P, Pfeffer S R (May. 2001). "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47". Science (UNITED STATES) 292 (5520): 1373–6. doi:10.1126/science.1056791. PMID 11359012.

Further reading

Shapiro AD, Pfeffer SR (1995). "Quantitative analysis of the interactions between prenyl Rab9, GDP dissociation inhibitor-alpha, and guanine nucleotides". J. Biol. Chem. 270 (19): 11085–90. doi:10.1074/jbc.270.19.11085. PMID 7744738.
Soldati T, Riederer MA, Pfeffer SR (1993). "Rab GDI: a solubilizing and recycling factor for rab9 protein". Mol. Biol. Cell 4 (4): 425–34. PMC 300943. PMID 8389620. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=300943.
Díaz E, Schimmöller F, Pfeffer SR (1997). "A novel Rab9 effector required for endosome-to-TGN transport". J. Cell Biol. 138 (2): 283–90. doi:10.1083/jcb.138.2.283. PMC 2138197. PMID 9230071. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2138197.
de Leeuw HP, Koster PM, Calafat J, et al. (1998). "Small GTP-binding proteins in human endothelial cells". Br. J. Haematol. 103 (1): 15–9. doi:10.1046/j.1365-2141.1998.00965.x. PMID 9792283.
Shisheva A, Chinni SR, DeMarco C (1999). "General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications". Biochemistry 38 (36): 11711–21. doi:10.1021/bi990200r. PMID 10512627.
Carroll KS, Hanna J, Simon I, et al. (2001). "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47". Science 292 (5520): 1373–6. doi:10.1126/science.1056791. PMID 11359012.
Orzaez D, de Jong AJ, Woltering EJ (2001). "A tomato homologue of the human protein PIRIN is induced during programmed cell death". Plant Mol. Biol. 46 (4): 459–68. doi:10.1023/A:1010618515051. PMID 11485202.
Michel F, Soler-Lopez M, Petosa C, et al. (2002). "Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family". EMBO J. 20 (22): 6180–90. doi:10.1093/emboj/20.22.6180. PMC 125740. PMID 11707390. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125740.
Barbero P, Bittova L, Pfeffer SR (2002). "Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells". J. Cell Biol. 156 (3): 511–8. doi:10.1083/jcb.200109030. PMC 2173336. PMID 11827983. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173336.
Hanna J, Carroll K, Pfeffer SR (2002). "Identification of residues in TIP47 essential for Rab9 binding". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7450–4. doi:10.1073/pnas.112198799. PMC 124251. PMID 12032303. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=124251.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Walter M, Davies JP, Ioannou YA (2004). "Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes". J. Lipid Res. 44 (2): 243–53. doi:10.1194/jlr.M200230-JLR200. PMID 12576506.
Seaman MN (2004). "Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer". J. Cell Biol. 165 (1): 111–22. doi:10.1083/jcb.200312034. PMC 2172078. PMID 15078902. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172078.
Chen L, DiGiammarino E, Zhou XE, et al. (2004). "High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target". J. Biol. Chem. 279 (38): 40204–8. doi:10.1074/jbc.M407114200. PMID 15263003.
Ganley IG, Carroll K, Bittova L, Pfeffer S (2005). "Rab9 GTPase regulates late endosome size and requires effector interaction for its stability". Mol. Biol. Cell 15 (12): 5420–30. doi:10.1091/mbc.E04-08-0747. PMC 532021. PMID 15456905. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=532021.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ganley IG, Pfeffer SR (2006). "Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells". J. Biol. Chem. 281 (26): 17890–9. doi:10.1074/jbc.M601679200. PMID 16644737.
Aivazian D, Serrano RL, Pfeffer S (2006). "TIP47 is a key effector for Rab9 localization". J. Cell Biol. 173 (6): 917–26. doi:10.1083/jcb.200510010. PMC 2063917. PMID 16769818. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2063917.

PDB gallery

1s8f: Crystal structure of Rab9 complexed to GDP reveals a dimer with an active conformation of switch II

1wms: High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target

1yzl: GppNHp-Bound Rab9 GTPase