RAB2A

RAB2A, member RAS oncogene family

PDB rendering based on 1z0a.

Available structures
PDB	1z0a, 2a5j

Identifiers

Symbols

RAB2A; LHX; RAB2

External IDs

OMIM: 179509 MGI: 1928750 HomoloGene: 20628 GeneCards: RAB2A Gene

Gene Ontology
Molecular function	• nucleotide binding • GTPase activity • GTP binding • GDP binding
Cellular component	• Golgi membrane • membrane fraction • soluble fraction • endoplasmic reticulum • endoplasmic reticulum membrane • Golgi apparatus • membrane • ER-Golgi intermediate compartment membrane • melanosome • neuronal cell body
Biological process	• GTP catabolic process • GTP catabolic process • ER to Golgi vesicle-mediated transport • small GTPase mediated signal transduction • protein transport • vesicle-mediated transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
61.43 – 61.54 Mb

Chr 4:
8.46 – 8.53 Mb

PubMed search

[1]

[2]

Ras-related protein Rab-2A is a protein that in humans is encoded by the RAB2A gene.^[1]

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rabs are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking. The mammalian RAB proteins show striking similarities to the S. cerevisiae YPT1 and SEC4 proteins, Ras-related GTP-binding proteins involved in the regulation of secretion.[supplied by OMIM]^[1]

Interactions

RAB2A has been shown to interact with GOLGA2.^[2]^[3]

References

^ ^a ^b "Entrez Gene: RAB2A RAB2A, member RAS oncogene family". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5862.
^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
^ Short, B; Preisinger C, Körner R, Kopajtich R, Byron O, Barr F A (Dec. 2001). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". J. Cell Biol. (United States) 155 (6): 877–83. doi:10.1083/jcb.200108079. ISSN 0021-9525. PMC 2150909. PMID 11739401. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150909.

Khosravi-Far R, Lutz RJ, Cox AD et al. (1991). "Isoprenoid modification of rab proteins terminating in CC or CXC motifs". Proc. Natl. Acad. Sci. U.S.A. 88 (14): 6264–8. doi:10.1073/pnas.88.14.6264. PMC 52063. PMID 1648736. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=52063.
Zahraoui A, Touchot N, Chardin P, Tavitian A (1989). "The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion". J. Biol. Chem. 264 (21): 12394–401. PMID 2501306.
Tachibana K, Umezawa A, Kato S, Takano T (1989). "Nucleotide sequence of a new YPT1-related human cDNA which belongs to the ras gene superfamily". Nucleic Acids Res. 16 (21): 10368. doi:10.1093/nar/16.21.10368. PMC 338870. PMID 3057444. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=338870.
Andersson B, Wentland MA, Ricafrente JY et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Tisdale EJ, Balch WE (1997). "Rab2 is essential for the maturation of pre-Golgi intermediates". J. Biol. Chem. 271 (46): 29372–9. doi:10.1074/jbc.271.46.29372. PMID 8910601.
Yu W, Andersson B, Worley KC et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146.
de Leeuw HP, Koster PM, Calafat J et al. (1998). "Small GTP-binding proteins in human endothelial cells". Br. J. Haematol. 103 (1): 15–9. doi:10.1046/j.1365-2141.1998.00965.x. PMID 9792283.
Shisheva A, Chinni SR, DeMarco C (1999). "General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications". Biochemistry 38 (36): 11711–21. doi:10.1021/bi990200r. PMID 10512627.
Caillol N, Pasqualini E, Lloubes R, Lombardo D (2000). "Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells". J. Cell. Biochem. 79 (4): 628–47. doi:10.1002/1097-4644(20001215)79:4<628::AID-JCB120>3.0.CO;2-T. PMID 10996854.
Short B, Preisinger C, Körner R et al. (2002). "A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic". J. Cell Biol. 155 (6): 877–83. doi:10.1083/jcb.200108079. PMC 2150909. PMID 11739401. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150909.
Ni X, Ma Y, Cheng H et al. (2002). "Molecular cloning and characterization of a novel human Rab ( Rab2B) gene". J. Hum. Genet. 47 (10): 548–51. doi:10.1007/s100380200083. PMID 12376746.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Tisdale EJ (2004). "Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation". J. Biol. Chem. 278 (52): 52524–30. doi:10.1074/jbc.M309343200. PMID 14570876.
Tisdale EJ, Kelly C, Artalejo CR (2005). "Glyceraldehyde-3-phosphate dehydrogenase interacts with Rab2 and plays an essential role in endoplasmic reticulum to Golgi transport exclusive of its glycolytic activity". J. Biol. Chem. 279 (52): 54046–52. doi:10.1074/jbc.M409472200. PMID 15485821.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Chi A, Valencia JC, Hu ZZ et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
Dong C, Wu G (2007). "Regulation of Anterograde Transport of Adrenergic and Angiotensin II Receptors by Rab2 and Rab6 GTPases". Cell. Signal. 19 (11): 2388–99. doi:10.1016/j.cellsig.2007.07.017. PMC 2072516. PMID 17716866. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2072516.

PDB gallery

1z0a: GDP-Bound Rab2A GTPase

2a5j: Crystal Structure of Human RAB2B

RAB2A

Interactions

References

Further reading