RAB1B

RAB1B, member RAS oncogene family

PDB rendering based on 2fol.

Available structures
PDB	3JZA, 3NKV

Identifiers

External IDs

OMIM: 612565 MGI: 1923558 HomoloGene: 49926 GeneCards: RAB1B Gene

Gene Ontology
Molecular function	• nucleotide binding • protein binding • GTP binding
Cellular component	• cytoplasm • mitochondrion • Golgi apparatus • membrane
Biological process	• small GTPase mediated signal transduction • protein transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000174903

ENSMUSG00000024870

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
66.04 – 66.04 Mb

Chr 19:
5.1 – 5.11 Mb

PubMed search

Ras-related protein Rab-1B is a protein that in humans is encoded by the RAB1B gene.^[1]^[2]

Interactions

RAB1B has been shown to interact with GOLGA2.^[3]

References

^ Chen D, Guo J, Gahl WA (Mar 1997). "RAB GTPases expressed in human melanoma cells". Biochim Biophys Acta 1355 (1): 1–6. doi:10.1016/S0167-4889(96)00169-3. PMID 9030196.
^ "Entrez Gene: RAB1B RAB1B, member RAS oncogene family". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81876.
^ Weide, T; Bayer M, Köster M, Siebrasse J P, Peters R, Barnekow A (Apr. 2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Rep. (England) 2 (4): 336–41. doi:10.1093/embo-reports/kve065. ISSN 1469-221X. PMC 1083862. PMID 11306556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083862.

Further reading

Plutner H, Cox AD, Pind S, et al. (1991). "Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments". J. Cell Biol. 115 (1): 31–43. doi:10.1083/jcb.115.1.31. PMC 2289927. PMID 1918138. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2289927.
Soldati T, Rancaño C, Geissler H, Pfeffer SR (1995). "Rab7 and Rab9 are recruited onto late endosomes by biochemically distinguishable processes". J. Biol. Chem. 270 (43): 25541–8. doi:10.1074/jbc.270.43.25541. PMID 7592724.
Wilson AL, Sheridan KM, Erdman RA, Maltese WA (1996). "Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells". Biochem. J. 318 ( Pt 3) (Pt 3): 1007–14. PMC 1217717. PMID 8836150. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1217717.
Overmeyer JH, Wilson AL, Erdman RA, Maltese WA (1998). "The Putative "Switch 2" Domain of the Ras-related GTPase, Rab1B, Plays an Essential Role in the Interaction with Rab Escort Protein". Mol. Biol. Cell 9 (1): 223–35. PMC 25245. PMID 9437002. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25245.
Weide T, Koster M, Barnekow A (1999). "Inactive and active mutants of rab1b are not tightly integrated into target membranes". Int. J. Oncol. 15 (4): 727–36. PMID 10493955.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732.
Weide T, Bayer M, Köster M, et al. (2001). "The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b". EMBO Rep. 2 (4): 336–41. doi:10.1093/embo-reports/kve065. PMC 1083862. PMID 11306556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083862.
Zhao H, Ettala O, Väänänen HK (2002). "Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins". Biochem. Biophys. Res. Commun. 293 (3): 1060–5. doi:10.1016/S0006-291X(02)00326-1. PMID 12051767.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
Bayer M, Fischer J, Kremerskothen J, et al. (2006). "Identification and characterization of Iporin as a novel interaction partner for rab1". BMC Cell Biol. 6: 15. doi:10.1186/1471-2121-6-15. PMC 1079803. PMID 15796781. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1079803.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
Monetta P, Slavin I, Romero N, Alvarez C (2007). "Rab1b Interacts with GBF1 and Modulates both ARF1 Dynamics and COPI Association". Mol. Biol. Cell 18 (7): 2400–10. doi:10.1091/mbc.E06-11-1005. PMC 1924811. PMID 17429068. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1924811.
Machner MP, Isberg RR (2007). "A bifunctional bacterial protein links GDI displacement to Rab1 activation". Science 318 (5852): 974–7. doi:10.1126/science.1149121. PMID 17947549.

PDB gallery

2fol: Crystal structure of human RAB1A in complex with GDP