RAB14

RAB14, member RAS oncogene family

PDB rendering based on 1z0f.

Available structures
PDB	1Z0F, 2AED

Identifiers

RAB14; FBP; RAB-14

External IDs

OMIM: 612673 MGI: 1915615 HomoloGene: 48679 GeneCards: RAB14 Gene

Gene Ontology
Molecular function	• nucleotide binding • glycoprotein binding • GTPase activity • GTPase activity • protein binding • GTP binding • GDP binding
Cellular component	• Golgi membrane • intracellular • intracellular • membrane fraction • lysosome • early endosome • late endosome • rough endoplasmic reticulum • Golgi apparatus • Golgi stack • cytosol • plasma membrane • apical plasma membrane • trans-Golgi network transport vesicle • early endosome membrane • nuclear outer membrane-endoplasmic reticulum membrane network • lamellar body • perinuclear region of cytoplasm
Biological process	• GTP catabolic process • GTP catabolic process • Golgi to endosome transport • Golgi to endosome transport • small GTPase mediated signal transduction • neurotransmitter secretion • body fluid secretion • fibroblast growth factor receptor signaling pathway • embryo development • protein transport • vesicle-mediated transport • regulation of protein localization • apical protein localization • intracellular transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000119396

ENSMUSG00000026878

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
123.94 – 123.99 Mb

Chr 2:
35.04 – 35.06 Mb

PubMed search

Ras-related protein Rab-14 is a protein that in humans is encoded by the RAB14 gene.^[1]^[2]^[3]

References

^ de Leeuw HP, Koster PM, Calafat J, Janssen H, van Zonneveld AJ, van Mourik JA, Voorberg J (Dec 1998). "Small GTP-binding proteins in human endothelial cells". Br J Haematol 103 (1): 15–9. doi:10.1046/j.1365-2141.1998.00965.x. PMID 9792283.
^ Junutula JR, De Maziere AM, Peden AA, Ervin KE, Advani RJ, van Dijk SM, Klumperman J, Scheller RH (Apr 2004). "Rab14 is involved in membrane trafficking between the Golgi complex and endosomes". Mol Biol Cell 15 (5): 2218–29. doi:10.1091/mbc.E03-10-0777. PMC 404017. PMID 15004230. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=404017.
^ "Entrez Gene: RAB14 RAB14, member RAS oncogene family". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51552.

Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16901.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
Garin J, Diez R, Kieffer S, et al. (2001). "The phagosome proteome: insight into phagosome functions.". J. Cell Biol. 152 (1): 165–80. doi:10.1083/jcb.152.1.165. PMC 2193653. PMID 11149929. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193653.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732.
Predic J, Soskic V, Bradley D, Godovac-Zimmermann J (2002). "Monitoring of gene expression by functional proteomics: response of human lung fibroblast cells to stimulation by endothelin-1.". Biochemistry 41 (3): 1070–8. doi:10.1021/bi0117854. PMID 11790131.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528930.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1347501.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.

PDB gallery

1z0f: GDP-Bound Rab14 GTPase

2aed: Crystal structure of human RAB14