RAB11FIP2

RAB11 family interacting protein 2 (class I)

PDB rendering based on 2gzd.

Available structures
PDB	2GZD, 2GZH, 2K6S

Identifiers

Symbols

RAB11FIP2; KIAA0941; Rab11-FIP2; nRip11

External IDs

OMIM: 608599 MGI: 1922248 HomoloGene: 8937 GeneCards: RAB11FIP2 Gene

Gene Ontology
Molecular function	• protein binding • protein homodimerization activity
Cellular component	• endosome • plasma membrane • recycling endosome membrane
Biological process	• protein transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
119.76 – 119.81 Mb

Chr 19:
59.98 – 60.02 Mb

PubMed search

[1]

[2]

Rab11 family-interacting protein 2 is a protein that in humans is encoded by the RAB11FIP2 gene.^[1]^[2]^[3]

Interactions

RAB11FIP2 has been shown to interact with MYO5B,^[4] RAB11A^[1]^[5]^[6] and RAB25.^[5]^[6]

References

^ ^a ^b Lindsay AJ, McCaffrey MW (Jul 2002). "Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain". J Biol Chem 277 (30): 27193–9. doi:10.1074/jbc.M200757200. PMID 11994279.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
^ "Entrez Gene: RAB11FIP2 RAB11 family interacting protein 2 (class I)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22841.
^ Hales, Chadwick M; Vaerman Jean-Pierre, Goldenring James R (Dec. 2002). "Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling". J. Biol. Chem. (United States) 277 (52): 50415–21. doi:10.1074/jbc.M209270200. ISSN 0021-9258. PMID 12393859.
^ ^a ^b Hales, C M; Griner R, Hobdy-Henderson K C, Dorn M C, Hardy D, Kumar R, Navarre J, Chan E K, Lapierre L A, Goldenring J R (Oct. 2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. (United States) 276 (42): 39067–75. doi:10.1074/jbc.M104831200. ISSN 0021-9258. PMID 11495908.
^ ^a ^b Prekeris, R; Davies J M, Scheller R H (Oct. 2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins". J. Biol. Chem. (United States) 276 (42): 38966–70. doi:10.1074/jbc.M106133200. ISSN 0021-9258. PMID 11481332.

Prekeris R, Davies JM, Scheller RH (2001). "Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins.". J. Biol. Chem. 276 (42): 38966–70. doi:10.1074/jbc.M106133200. PMID 11481332.
Hales CM, Griner R, Hobdy-Henderson KC et al. (2001). "Identification and characterization of a family of Rab11-interacting proteins". J. Biol. Chem. 276 (42): 39067–75. doi:10.1074/jbc.M104831200. PMID 11495908.
Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2002). "The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities". Biochem. Biophys. Res. Commun. 292 (4): 909–15. doi:10.1006/bbrc.2002.6736. PMID 11944901.
Cullis DN, Philip B, Baleja JD, Feig LA (2003). "Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors". J. Biol. Chem. 277 (51): 49158–66. doi:10.1074/jbc.M206316200. PMID 12364336.
Hales CM, Vaerman JP, Goldenring JR (2003). "Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling". J. Biol. Chem. 277 (52): 50415–21. doi:10.1074/jbc.M209270200. PMID 12393859.
Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW (2003). "Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells". Biochem. Biophys. Res. Commun. 299 (5): 770–9. doi:10.1016/S0006-291X(02)02720-1. PMID 12470645.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Fan GH, Lapierre LA, Goldenring JR et al. (2005). "Rab11-Family Interacting Protein 2 and Myosin Vb Are Required for CXCR2 Recycling and Receptor-mediated Chemotaxis". Mol. Biol. Cell 15 (5): 2456–69. doi:10.1091/mbc.E03-09-0706. PMC 404037. PMID 15004234. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=404037.
Junutula JR, Schonteich E, Wilson GM et al. (2004). "Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins". J. Biol. Chem. 279 (32): 33430–7. doi:10.1074/jbc.M404633200. PMID 15173169.
Lindsay AJ, McCaffrey MW (2005). "The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane". J. Cell. Sci. 117 (Pt 19): 4365–75. doi:10.1242/jcs.01280. PMID 15304524.
Jin J, Smith FD, Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Naslavsky N, Rahajeng J, Sharma M et al. (2006). "Interactions between EHD Proteins and Rab11-FIP2: A Role for EHD3 in Early Endosomal Transport". Mol. Biol. Cell 17 (1): 163–77. doi:10.1091/mbc.E05-05-0466. PMC 1345656. PMID 16251358. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1345656.
Ducharme NA, Hales CM, Lapierre LA et al. (2006). "MARK2/EMK1/Par-1Bα Phosphorylation of Rab11-Family Interacting Protein 2 Is Necessary for the Timely Establishment of Polarity in Madin-Darby Canine Kidney Cells". Mol. Biol. Cell 17 (8): 3625–37. doi:10.1091/mbc.E05-08-0736. PMC 1525241. PMID 16775013. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1525241.
Ducharme NA, Williams JA, Oztan A et al. (2007). "Rab11-FIP2 regulates differentiable steps in transcytosis". Am. J. Physiol., Cell Physiol. 293 (3): C1059–72. doi:10.1152/ajpcell.00078.2007. PMID 17626244.

PDB gallery

2gzd: Crystal Structure of Rab11 in Complex with Rab11-FIP2

2gzh: Crystal Structure of Rab11 in Complex with Rab11-Family Interacting Protein 2

RAB11FIP2

Interactions

References

Further reading