RAB10

RAB10, member RAS oncogene family

Identifiers

External IDs

OMIM: 612672 MGI: 105066 HomoloGene: 41111 GeneCards: RAB10 Gene

Gene Ontology
Molecular function	• nucleotide binding • protein binding • GTP binding
Cellular component	• Golgi apparatus • plasma membrane
Biological process	• small GTPase mediated signal transduction • protein transport
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000084733

ENSMUSG00000020671

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
26.26 – 26.36 Mb

Chr 12:
3.25 – 3.31 Mb

PubMed search

Ras-related protein Rab-10 is a protein that in humans is encoded by the RAB10 gene.^[1]^[2]

Interactions

RAB10 has been shown to interact with AP1S1.^[3]

References

^ Chen YT, Holcomb C, Moore HP (Aug 1993). "Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag". Proc Natl Acad Sci U S A 90 (14): 6508–12. doi:10.1073/pnas.90.14.6508. PMC 46961. PMID 7688123. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=46961.
^ "Entrez Gene: RAB10 RAB10, member RAS oncogene family". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10890.
^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.

Further reading

Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects.". Horm. Metab. Res. 30 (11): 656–62. doi:10.1055/s-2007-978953. PMID 9918381.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16901.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Fukuda M (2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.". J. Biol. Chem. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Sonkoly E, Bata-Csorgo Z, Pivarcsi A, et al. (2005). "Identification and characterization of a novel, psoriasis susceptibility-related noncoding RNA gene, PRINS.". J. Biol. Chem. 280 (25): 24159–67. doi:10.1074/jbc.M501704200. PMID 15855153.
Larance M, Ramm G, Stöckli J, et al. (2006). "Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking.". J. Biol. Chem. 280 (45): 37803–13. doi:10.1074/jbc.M503897200. PMID 16154996.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.