Mepyramine

Mepyramine
Systematic (IUPAC) name
N-(4-methoxybenzyl)-N',N'-dimethyl-N-pyridin-2-ylethane-1,2-diamine
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a606008
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 91-84-9 Y
59-33-6 (maleate)
ATC code R06AC01 D04AA02
PubChem CID 4992
IUPHAR ligand 1220
DrugBank DB06691
ChemSpider 4818 Y
UNII HPE317O9TL Y
KEGG D08183 Y
ChEBI CHEBI:6762 N
ChEMBL CHEMBL511 Y
Synonyms N-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine
Chemical data
Formula C17H23N3O 
Mol. mass 285.38 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Mepyramine, also known as pyrilamine, is a first generation antihistamine, targeting the H1 receptor.[1] However, it rapidly permeates the brain often causing drowsiness. It also has anticholinergic properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms.[2] It is also the active ingredient of the topical antihistamine creams Anthisan and Neoantergan, sold for the treatment of insect bites, stings and nettle rash.

References

  1. ^ Parsons, M. E. and Ganellin, C. R. (2006). "Histamine and its receptors". British Journal of Pharmacology 147 (S1): S127–S135. doi:10.1038/sj.bjp.0706440. PMC 1760721. PMID 16402096. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1760721. 
  2. ^ Active Ingredients for Midol Complete
Antihistamines for topical use
Anesthetics for topical use

M: INT, SF, LCT

anat/phys/devp

noco(i/b/d/q/u/r/p/m/k/v/f)/cong/tumr(n/e/d), sysi/epon

proc, drug (D2/3/4/5/8/11)