Pyrazole | |
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Pyrazole |
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Other names
1,2-Diazole |
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Identifiers | |
CAS number | 288-13-1 |
PubChem | 1048 |
ChemSpider | 1019 |
DrugBank | DB02757 |
KEGG | C00481 |
ChEBI | CHEBI:17241 |
ChEMBL | CHEMBL15967 |
Jmol-3D images | Image 1 |
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Properties | |
Molecular formula | C3H4N2 |
Molar mass | 68.08 g mol−1 |
Melting point |
66-70 °C |
Boiling point |
186-188 °C |
Acidity (pKa) | 14.0 |
Basicity (pKb) | 2.5 |
(verify) (what is: / ?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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Infobox references |
Pyrazole refers both to the class of simple aromatic ring organic compounds of the heterocyclic diazole series characterized by a 5-membered ring structure composed of three carbon atoms and two nitrogen atoms in adjacent positions, and to the unsubstituted parent compound. Being so composed and having pharmacological effects on humans, they are classified as alkaloids, although they are rare in nature.[1] In 1959, the first natural pyrazole, 1-pyrazolyl-alanine, was isolated from seeds of watermelons. The term pyrazole was given to this class of compounds by Ludwig Knorr in 1883.
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In medicine, derivatives of pyrazoles are used for their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, tranquilizing, muscle relaxing, psychoanaleptic, anticonvulsant, monoamineoxidase inhibiting, antidiabetic and antibacterial activities.