Pyrazole

Pyrazole
Identifiers
CAS number 288-13-1 Y
PubChem 1048
ChemSpider 1019 Y
DrugBank DB02757
KEGG C00481 Y
ChEBI CHEBI:17241 Y
ChEMBL CHEMBL15967 Y
Jmol-3D images Image 1
Properties
Molecular formula C3H4N2
Molar mass 68.08 g mol−1
Melting point

66-70 °C

Boiling point

186-188 °C

Acidity (pKa) 14.0
Basicity (pKb) 2.5
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Pyrazole refers both to the class of simple aromatic ring organic compounds of the heterocyclic diazole series characterized by a 5-membered ring structure composed of three carbon atoms and two nitrogen atoms in adjacent positions, and to the unsubstituted parent compound. Being so composed and having pharmacological effects on humans, they are classified as alkaloids, although they are rare in nature.[1] In 1959, the first natural pyrazole, 1-pyrazolyl-alanine, was isolated from seeds of watermelons. The term pyrazole was given to this class of compounds by Ludwig Knorr in 1883.

Contents

Reactions

Uses

In medicine, derivatives of pyrazoles are used for their analgesic, anti-inflammatory, antipyretic, antiarrhythmic, tranquilizing, muscle relaxing, psychoanaleptic, anticonvulsant, monoamineoxidase inhibiting, antidiabetic and antibacterial activities.

See also

References

  1. ^ Eicher, T.; Hauptmann, S. (2nd ed. 2003). The Chemistry of Heterocycles: Structure, Reactions, Syntheses, and Applications. Wiley-VCH. ISBN 3527307206. 
  2. ^ Pyrazol aus Acetylen und Diazomethan H. v. Pechmann Berichte der deutschen chemischen Gesellschaft Volume 31 Issue 3, Pages 2950 - 2951 1898 doi:10.1002/cber.18980310363

External links