Pulmonary surfactant-associated protein B
Pulmonary surfactant-associated protein B is a protein that in humans is encoded by the SFTPB gene.[1][2][3]
Pulmonary surfactant-associated protein B' is a membrane protein which manufactures surfactant.
Clinical significance
Humans and animals born with a congenital absence of SP-B suffer from intractable respiratory failure.
It is associated with Surfactant metabolism dysfunction type 1.
See also
References
- ^ Pilot-Matias TJ, Kister SE, Fox JL, Kropp K, Glasser SW, Whitsett JA (May 1989). "Structure and organization of the gene encoding human pulmonary surfactant proteolipid SP-B". DNA 8 (2): 75–86. doi:10.1089/dna.1.1989.8.75. PMID 2924687.
- ^ Moore KJ, D'Amore-Bruno MA, Korfhagen TR, Glasser SW, Whitsett JA, Jenkins NA, Copeland NG (Mar 1992). "Chromosomal localization of three pulmonary surfactant protein genes in the mouse". Genomics 12 (2): 388–93. doi:10.1016/0888-7543(92)90389-A. PMID 1346779.
- ^ "Entrez Gene: SFTPB surfactant, pulmonary-associated protein B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6439.
Further reading
- Pérez-Gil J (2002). "Lipid-protein interactions of hydrophobic proteins SP-B and SP-C in lung surfactant assembly and dynamics". Pediatric pathology & molecular medicine 20 (6): 445–69. PMID 11699574.
- Johansson J, Curstedt T, Robertson B (2002). "Artificial surfactants based on analogues of SP-B and SP-C". Pediatric pathology & molecular medicine 20 (6): 501–18. PMID 11699576.
- Nogee LM (2004). "Alterations in SP-B and SP-C expression in neonatal lung disease". Annu. Rev. Physiol. 66: 601–23. doi:10.1146/annurev.physiol.66.032102.134711. PMID 14977415.
- Voorhout WF, Veenendaal T, Haagsman HP et al. (1992). "Intracellular processing of pulmonary surfactant protein B in an endosomal/lysosomal compartment". Am. J. Physiol. 263 (4 Pt 1): L479–86. PMID 1415726.
- Johansson J, Jörnvall H, Curstedt T (1992). "Human surfactant polypeptide SP-B. Disulfide bridges, C-terminal end, and peptide analysis of the airway form". FEBS Lett. 301 (2): 165–7. doi:10.1016/0014-5793(92)81239-I. PMID 1568474.
- Yu SH, Possmayer F (1992). "Effect of pulmonary surfactant protein B (SP-B) and calcium on phospholipid adsorption and squeeze-out of phosphatidylglycerol from binary phospholipid monolayers containing dipalmitoylphosphatidylcholine". Biochim. Biophys. Acta 1126 (1): 26–34. PMID 1606172.
- Weaver TE, Whitsett JA (1989). "Processing of hydrophobic pulmonary surfactant protein B in rat type II cells". Am. J. Physiol. 257 (2 Pt 1): L100–8. PMID 2475034.
- Glasser SW, Korfhagen TR, Weaver T et al. (1987). "cDNA and deduced amino acid sequence of human pulmonary surfactant-associated proteolipid SPL(Phe)". Proc. Natl. Acad. Sci. U.S.A. 84 (12): 4007–11. doi:10.1073/pnas.84.12.4007. PMC 305010. PMID 3035561. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305010.
- Revak SD, Merritt TA, Degryse E et al. (1988). "Use of human surfactant low molecular weight apoproteins in the reconstitution of surfactant biologic activity". J. Clin. Invest. 81 (3): 826–33. doi:10.1172/JCI113391. PMC 442533. PMID 3343343. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442533.
- Jacobs KA, Phelps DS, Steinbrink R et al. (1987). "Isolation of a cDNA clone encoding a high molecular weight precursor to a 6-kDa pulmonary surfactant-associated protein". J. Biol. Chem. 262 (20): 9808–11. PMID 3597440.
- Vamvakopoulos NC, Modi WS, Floros J (1994). "Mapping the human pulmonary surfactant-associated protein B gene (SFTP3) to chromosome 2p12→p11.2". Cytogenet. Cell Genet. 68 (1–2): 8–10. doi:10.1159/000133878. PMID 7956367.
- Nogee LM, Garnier G, Dietz HC et al. (1994). "A mutation in the surfactant protein B gene responsible for fatal neonatal respiratory disease in multiple kindreds". J. Clin. Invest. 93 (4): 1860–3. doi:10.1172/JCI117173. PMC 294267. PMID 8163685. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=294267.
- Stuhrmann M, Bohnhorst B, Peters U et al. (1999). "Prenatal diagnosis of congenital alveolar proteinosis (surfactant protein B deficiency)". Prenat. Diagn. 18 (9): 953–5. doi:10.1002/(SICI)1097-0223(199809)18:9<953::AID-PD364>3.0.CO;2-J. PMID 9793979.
- Wallot M, Wagenvoort C, deMello D et al. (1999). "Congenital alveolar proteinosis caused by a novel mutation of the surfactant protein B gene and misalignment of lung vessels in consanguineous kindred infants". Eur. J. Pediatr. 158 (6): 513–8. doi:10.1007/s004310051132. PMID 10378403.
- Tredano M, van Elburg RM, Kaspers AG et al. (2000). "Compound SFTPB 1549C-->GAA (121ins2) and 457delC heterozygosity in severe congenital lung disease and surfactant protein B (SP-B) deficiency". Hum. Mutat. 14 (6): 502–9. doi:10.1002/(SICI)1098-1004(199912)14:6<502::AID-HUMU9>3.0.CO;2-C. PMID 10571948.
- Korimilli A, Gonzales LW, Guttentag SH (2000). "Intracellular localization of processing events in human surfactant protein B biosynthesis". J. Biol. Chem. 275 (12): 8672–9. doi:10.1074/jbc.275.12.8672. PMID 10722708.
- Gordon LM, Lee KY, Lipp MM et al. (2000). "Conformational mapping of the N-terminal segment of surfactant protein B in lipid using 13C-enhanced Fourier transform infrared spectroscopy". J. Pept. Res. 55 (4): 330–47. doi:10.1034/j.1399-3011.2000.00693.x. PMID 10798379.
- Lin Z, Pearson C, Chinchilli V et al. (2001). "Polymorphisms of human SP-A, SP-B, and SP-D genes: association of SP-B Thr131Ile with ARDS". Clin. Genet. 58 (3): 181–91. doi:10.1034/j.1399-0004.2000.580305.x. PMID 11076040.
External links