| Proamanullin | |
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Other names
2-L-Proline-3-isoleucine-alpha-amanitin |
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| Identifiers | |
| CAS number | 54532-46-6 |
| PubChem | 171350 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C39H54N10O11S |
| Molar mass | 870.97 g/mol |
| Appearance | Colorless, odorless |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Promanullin is a cyclic nonribosomal peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms.
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Like other amatoxins, proamanullin is an inhibitor of RNA polymerase II. Promanullin has a specific attraction to the enzyme RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme, effectively causing cytolysis of hepatocytes (liver cells).[1]
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