Polyozellin

Polyozellin
IUPAC name

6,12-Diacetoxy-2,3,8,9-tetrahydroxybenzo[1,2-b;4,5-b']bisbenzofuran
Identifiers
CAS number 197703-46-1 Y
PubChem 382514
ChEMBL CHEMBL458248 N
Jmol-3D images Image 1
Properties
Molecular formula C22H14O10
Molar mass 438.34 g mol−1
Exact mass 438.058696 u
 N (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Polyozellin is a chemical which occurs in the mushroom Polyozellus multiplex. It inhibits prolyl endopeptidase , an enzyme that has a role in processing proteins (specifically, amyloid precursor protein) in Alzheimer's disease. Chemicals that inhibit prolyl endopeptidase have attracted research interest due to their potential therapeutic effects.[1] Structurally-related dibenzofuranyl derivatives of polyozellin are known as kynapcins.[2]

References

  1. ^ Hwang JS, Song KS, Kim WG, Lee TH, Koshino H, Yoo ID. (1997). "Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex". The Journal of Antibiotics 50 (9): 773–77. PMID 9360624. 
  2. ^ Kim SI, Park IH, Song KS. (2002). "kynapcin-13 and -28, new benzofuran prolyl endopeptidase inhibitors from Polyozellus multiplex". The Journal of Antibiotics 55 (7): 623–28. PMID 12243451.