Plasmacytoma
Plasmacytoma refers to a malignant plasma cell tumor[1] growing within soft tissue or within the skeleton. The skeletal forms usually have other occult tumors and frequently disseminate to multiple myeloma over the course of 5–10 years. The soft tissue forms most often occur in the upper respiratory tract, rarely disseminate, and are cured by resection. Most but not all cases produce paraproteinemia. Solitary tumors in bone can be treated by radiotherapy.
Terminology
There can be some ambiguity when using the word.
"Plasmacytoma" is sometimes equated with "plasma cell dyscrasia" or "solitary myeloma".[2]
It is often used as part of the phrase "solitary plasmacytoma".[3][4][5]
It is also used as part of the phrase "extramedullary plasmacytoma ".[6][7] In this context, "extramedullary" means outside of the bone marrow.
Diagnosis
It is diagnosed by immunoglobulin electrophoresis (or Serum protein electrophoresis) and bone marrow biopsy. Immunoglobulin electrophoresis will show a monoclonal M spike, but bone marrow biopsy will fail to find the classical signs of multiple myeloma. After those two determinations are made, search for the primary site in the soft tissue begins.
Gallery
See also
References
- ^ "CRC - Glossary P". http://cll.ucsd.edu/glossaryp.htm. Retrieved 2009-03-02.
- ^ "plasmacytoma" at Dorland's Medical Dictionary
- ^ Dimopoulos MA, Moulopoulos LA, Maniatis A, Alexanian R (September 2000). "Solitary plasmacytoma of bone and asymptomatic multiple myeloma". Blood 96 (6): 2037–44. PMID 10979944. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=10979944.
- ^ Di Micco P, Di Micco B (March 2005). "Up-date on solitary plasmacytoma and its main differences with multiple myeloma". Exp. Oncol. 27 (1): 7–12. PMID 15812350. http://www.exp-oncology.com.ua/en/archives/21/383.html.
- ^ Dingli D, Kyle RA, Rajkumar SV, et al. (September 2006). "Immunoglobulin free light chains and solitary plasmacytoma of bone". Blood 108 (6): 1979–83. doi:10.1182/blood-2006-04-015784. PMC 1895544. PMID 16741249. http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=16741249.
- ^ Megat Shiraz MA, Jong YH, Primuharsa Putra SH (November 2008). "Extramedullary plasmacytoma in the maxillary sinus". Singapore Med J 49 (11): e310–1. PMID 19037537. http://smj.sma.org.sg/4911/4911cr6.pdf.
- ^ Bink K, Haralambieva E, Kremer M, et al. (April 2008). "Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics". Haematologica 93 (4): 623–6. doi:10.3324/haematol.12005. PMID 18326524. http://www.haematologica.org/cgi/pmidlookup?view=long&pmid=18326524.
External links
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see immunoproliferative immunoglobulin disorders
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T or NK
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Lymphoid+myeloid
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| Cutaneous lymphoid hyperplasia |
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cell/phys/auag/auab/comp, igrc
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