| Systematic (IUPAC) name | |
|---|---|
| 1-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)piperidine | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | Uncontrolled |
| Routes | Oral |
| Identifiers | |
| CAS number | 59-39-2 135-87-5 (hydrochloride) |
| ATC code | None |
| PubChem | CID 6040 |
| ChemSpider | 5817 |
| UNII | 9ZCS27634Y |
| ChEMBL | CHEMBL31836 |
| Chemical data | |
| Formula | C14H19NO2 |
| Mol. mass | 233.31 g/mol |
| SMILES | eMolecules & PubChem |
Piperoxan, also known as benodaine or benzodioxane, is a drug which was the very first antihistamine ever to be discovered.[1][2] It was prepared in the early 1930s by Daniel Bovet and Ernest Fourneau at the Pasteur Institute in France.[1][2] Formerly investigated by Fourneau as an α-adrenergic-blocking agent, they demonstrated that it also antagonized histamine-induced bronchospasm in guinea pigs, and published their findings in 1933.[1][2][3] Bovet went on to win the 1957 Nobel Prize in Physiology or Medicine for his contribution,[4] and one of their students, Anne-Marie Staub, published the first structure-activity relationship (SAR) study of antihistamines in 1939.[1]
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