Pinacidil

Pinacidil

IUPAC name N-cyano-N'-pyridin-4-yl-N''-(1,2,2-trimethylpropyl)guanidine
Identifiers
CAS number	85371-64-8^N
PubChem	4826
ChEMBL	CHEMBL1159^N, CHEMBL1200338
IUPHAR ligand	2412
ATC code	C02DG01
Jmol-3D images	Image 1
SMILES CC(C(C)(C)C)N=C(NC#N)NC1=CC=NC=C1
Properties
Molecular formula	C₁₃H₁₉N₅
Molar mass	245.32346
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Pinacidil is a cyanoguanidine drug that opens ATP-sensitive potassium channels producing peripheral vasodilatation of arterioles.^[1] It reduces blood pressure and peripheral resistance and produces fluid retention.^[2]

References

^ Gollasch M, Bychkov R, Ried C, Behrendt F, Scholze S, Luft FC, Haller H (1995). "Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells". J. Pharmacol. Exp. Ther. 275 (2): 681–92. PMID 7473155. http://jpet.aspetjournals.org/cgi/content/abstract/275/2/681.
^ Reynolds, James Blair; Martindale, William L. (1996). The extra pharmacopoeia (31st ed.). London: Royal Pharmaceutical Society. pp. 2739 pages. ISBN 0-85369-342-0.