Pick operating system, a computer operating system built around a multidimensional, variable data length database, often called "the Pick system" or simply "Pick"
Pick matrix, a specific type of matrix (mathematics)
Cherry picking, literally meaning harvesting cherries, used metaphorically to accuse someone of pointing at individual cases which seem to confirm his or her position, while ignoring a significant portion of related cases that may contradict it
Hammer and pick, the Bergeisen part of the Schlägel und Eisen symbol
Nose-picking, the act of extracting mucus or foreign bodies from the nose with a finger
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