Phosphatidylinositol 3,5-bisphosphate

Phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P2 or PI(3,5)P2) is a minor phospholipid component of cell membranes, yet important in distinguishing cell compartments. The generation of PtdIns(3,5)P2 in intracellular membranes by the lipid kinase PIKfyve recruits a number of important proteins involved in regulating intracellular trafficking[1].

PtdIns(3,5)P2 is dephophosphorylated at the 5 position by the phosphatase FIG4, and by members of the myotubularin lipid phosphatase family at the 3 position of the inositol ring generating Phosphatidylinositol 5-phosphate (PtdIns5P).

The phosphoinositide-binding domain in a number of proteins binds to PtdIns(3,5)P2, including the PH domain in centaurin-β2 , the PX domain of SNX1 , and a WD40 repeat domain in Atg18p[2].

References

  1. ^ Michell RH, Heath VL, Lemmon MA, Dove SK (January 2006). "Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions". Trends Biochem. Sci. 31 (1): 52–63. doi:10.1016/j.tibs.2005.11.013. PMID 16364647. 
  2. ^ Dove SK, Piper RC, McEwen RK, et al. (May 2004). "Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors". EMBO J. 23 (9): 1922–33. doi:10.1038/sj.emboj.7600203. PMC 404323. PMID 15103325. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=404323. 

External links

Glycerol backbone
(Glycerophospholipids/
Phosphoglycerides)
Sphingosine backbone
Metabolites

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
biochemical families: prot · nucl · carb (glpr, alco, glys) · lipd (fata/i, phld, strd, gllp, eico) · amac/i · ncbs/i · ttpy/i