PTPRZ1

Protein tyrosine phosphatase, receptor-type, Z polypeptide 1

Identifiers

PTPRZ1; HPTPZ; HPTPzeta; PTP-ZETA; PTP18; PTPRZ; PTPZ; RPTPB; RPTPbeta; phosphacan

External IDs

OMIM: 176891 MGI: 97816 HomoloGene: 2136 GeneCards: PTPRZ1 Gene

3.1.3.48

Gene Ontology
Molecular function	• transmembrane receptor protein tyrosine phosphatase activity • protein binding • protein tyrosine/threonine phosphatase activity • hydrolase activity
Cellular component	• proteinaceous extracellular matrix • integral to plasma membrane • membrane
Biological process	• protein dephosphorylation • axonogenesis • central nervous system development
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
121.51 – 121.7 Mb

Chr 6:
22.83 – 23 Mb

PubMed search

[1]

[2]

Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1 gene.^[1]^[2]^[3]

1 Function
2 Clinical significance
3 References
4 Further reading

Function

This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.^[3]

Clinical significance

Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration.^[3]

References

^ Ariyama T, Hasegawa K, Inazawa J, Mizuno K, Ogimoto M, Katagiri T, Yakura H (Jun 1995). "Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3". Cytogenet Cell Genet 70 (1–2): 52–4. doi:10.1159/000133990. PMID 7736789.
^ Levy JB, Canoll PD, Silvennoinen O, Barnea G, Morse B, Honegger AM, Huang JT, Cannizzaro LA et al. (Jun 1993). "The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system". J Biol Chem 268 (14): 10573–81. PMID 8387522.
^ ^a ^b ^c "Entrez Gene: PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5803.

Krueger NX, Saito H (1992). "A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases". Proc. Natl. Acad. Sci. U.S.A. 89 (16): 7417–21. doi:10.1073/pnas.89.16.7417. PMC 49721. PMID 1323835. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=49721.
Kaplan R, Morse B, Huebner K et al. (1990). "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain". Proc. Natl. Acad. Sci. U.S.A. 87 (18): 7000–4. doi:10.1073/pnas.87.18.7000. PMC 54670. PMID 2169617. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=54670.
Krueger NX, Streuli M, Saito H (1990). "Structural diversity and evolution of human receptor-like protein tyrosine phosphatases". EMBO J. 9 (10): 3241–52. PMC 552056. PMID 2170109. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=552056.
Morton SM, Veile RA, Helms C et al. (1998). "Subregional localization of 21 chromosome 7-specific expressed sequence tags (ESTs) by FISH using newly identified YACs and P1s". Genomics 46 (3): 491–4. doi:10.1006/geno.1997.5051. PMID 9441757.
Onyango P, Lubyova B, Gardellin P et al. (1998). "Molecular cloning and expression analysis of five novel genes in chromosome 1p36". Genomics 50 (2): 187–98. doi:10.1006/geno.1997.5186. PMID 9653645.
<Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Maeda N, Ichihara-Tanaka K, Kimura T et al. (1999). "A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta". J. Biol. Chem. 274 (18): 12474–9. doi:10.1074/jbc.274.18.12474. PMID 10212223.
Kawachi H, Tamura H, Watakabe I et al. (1999). "Protein tyrosine phosphatase zeta/RPTPbeta interacts with PSD-95/SAP90 family". Brain Res. Mol. Brain Res. 72 (1): 47–54. doi:10.1016/S0169-328X(99)00204-1. PMID 10521598.
Meng K, Rodriguez-Peña A, Dimitrov T et al. (2000). "Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2603–8. doi:10.1073/pnas.020487997. PMC 15975. PMID 10706604. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15975.
Kawachi H, Fujikawa A, Maeda N, Noda M (2001). "Identification of GIT1/Cat-1 as a substrate molecule of protein tyrosine phosphatase zeta /beta by the yeast substrate-trapping system". Proc. Natl. Acad. Sci. U.S.A. 98 (12): 6593–8. doi:10.1073/pnas.041608698. PMC 34398. PMID 11381105. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=34398.
Thomaidou D, Coquillat D, Meintanis S et al. (2001). "Soluble forms of NCAM and F3 neuronal cell adhesion molecules promote Schwann cell migration: identification of protein tyrosine phosphatases zeta/beta as the putative F3 receptors on Schwann cells". J. Neurochem. 78 (4): 767–78. doi:10.1046/j.1471-4159.2001.00454.x. PMID 11520897.
Harroch S, Furtado GC, Brueck W et al. (2002). "A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions". Nat. Genet. 32 (3): 411–4. doi:10.1038/ng1004. PMID 12355066.
Scherer SW, Cheung J, MacDonald JR et al. (2003). "Human chromosome 7: DNA sequence and biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961.
Müller S, Kunkel P, Lamszus K et al. (2003). "A role for receptor tyrosine phosphatase zeta in glioma cell migration". Oncogene 22 (43): 6661–8. doi:10.1038/sj.onc.1206763. PMID 14555979.
Bonora E, Lamb JA, Barnby G et al. (2005). "Mutation screening and association analysis of six candidate genes for autism on chromosome 7q". Eur. J. Hum. Genet. 13 (2): 198–207. doi:10.1038/sj.ejhg.5201315. PMID 15523497.
Polykratis A, Katsoris P, Courty J, Papadimitriou E (2005). "Characterization of heparin affin regulatory peptide signaling in human endothelial cells". J. Biol. Chem. 280 (23): 22454–61. doi:10.1074/jbc.M414407200. PMID 15797857.
Wang V, Davis DA, Haque M et al. (2005). "Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells". Cancer Res. 65 (8): 3299–306. doi:10.1158/0008-5472.CAN-04-4130. PMID 15833863.
Lu KV, Jong KA, Kim GY et al. (2005). "Differential induction of glioblastoma migration and growth by two forms of pleiotrophin". J. Biol. Chem. 280 (29): 26953–64. doi:10.1074/jbc.M502614200. PMID 15908427.

Esterase: protein tyrosine phosphatases (EC 3.1.3.48)

Class I

Classical PTPs	Receptor type PTPs (PTPRA, PTPRB, PTPRC, PTPRD, PTPRE, PTPRF, PTPRG, PTPRH, PTPRJ, PTPRK, PTPRM, PTPRN, PTPRN2, PTPRO, PTPRQ, PTPRR, PTPRS, PTPRT, PTPRU, PTPRZ1, PTPRZ2) Non receptor type PTPs (PTPN1, PTPN2, PTPN3, PTPN4, PTPN5, PTPN6, PTPN7, PTPN9, PTPN11, PTPN12, PTPN13, PTPN14, PTPN18, PTPN20, PTPN21, PTPN22, PTPN23

VH1-like or dual specific phosphatases (DSPs)	MAPK phosphatases (MKPs) (DUSP1, DUSP2, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, DUSP10, DUSP16, MK-STYX) Slingshots (SSH1, SSH2, SSH3) PRLs (PTP4A1, PTP4A2, PTP4A3) CDC14s (CDC14A, CDC14B, CDKN3, PTP9Q22) Atypical DSPs (DUSP3, DUSP11, DUSP12, DUSP13A, DUSP13B, DUSP14, DUSP15, DUSP18, DUSP19, DUSP21, DUSP22, DUSP23, DUSP24, DUSP25, DUSP26, DUSP27, EMP2A, RNGTT, STYX) Phosphatase and tensin homologs (PTENs) (PTEN, TPIP, TPTE, TNS, TENC1) Myotubularins (MTM1, MTMR2, MTMR3, MTMR4, MTMR5, MTMR6, MTMR7, MTMR8, MTMR9, MTMR10, MTMR11, MTMR12, MTMR13, MTMR14, MTMR15)

Class II

ACP1

Class III

Cdc25: CDC25A, CDC25B, CDC25C

Class IV

Eyes absent homolog (EYA1, EYA2, EYA3, EYA4)

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

PTPRZ1

Contents

Function

Clinical significance

References

Further reading