JWH-167

JWH-167
IUPAC name

2-phenyl-1-(1-pentylindol-3-yl)ethanone
Other names

1-(1-pentyl-1H-indol-3-yl)-2-phenylethanone
Identifiers
CAS number 864445-37-4 N
PubChem 44397502
ChemSpider 23256084 Y
ChEMBL CHEMBL365878 Y
Jmol-3D images Image 1
Properties
Molecular formula C21H23NO
Molar mass 305.41 g mol−1
 N (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

JWH-167 (1-pentyl-3-(phenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 1.75x selectivity for CB2 with a Ki of 90nM ± 17 and 159nM ± 14 at CB1. Similar to the related 2'-methoxy compound JWH-250, and the 2'-chloro compound JWH-203, JWH-167 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds.[1][2]

References

  1. ^ Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL et al. (2005). "1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles". Bioorganic & medicinal chemistry letters 15 (18): 4110–3. doi:10.1016/j.bmcl.2005.06.008. PMID 16005223. 
  2. ^ Manera C, Tuccinardi T, Martinelli A (2008). "Indoles and related compounds as cannabinoid ligands". Mini reviews in medicinal chemistry 8 (4): 370–87. doi:10.2174/138955708783955935. PMID 18473928.