PAX4

Paired box 4
Identifiers
Symbols PAX4; KPD; MGC129960; MODY9
External IDs OMIM: 167413 MGI: 97488 HomoloGene: 4515 GeneCards: PAX4 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5078 18506
Ensembl ENSG00000106331 ENSMUSG00000029706
UniProt O43316 Q9EQ02
RefSeq (mRNA) NM_006193 NM_011038
RefSeq (protein) NP_006184 NP_035168
Location (UCSC) Chr 7:
127.25 – 127.26 Mb		 Chr 6:
28.39 – 28.4 Mb
PubMed search [1] [2]

Paired box gene 4, also known as PAX4, is a protein which in humans is encoded by the PAX4 gene.[1][2][3]

Contents

Function

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box gene 4 is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.[1]

See also

References

  1. ^ a b "Entrez Gene: PAX4 paired box gene 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5078. 
  2. ^ Matsushita T, Yamaoka T, Otsuka S, Moritani M, Matsumoto T, Itakura M (January 1998). "Molecular cloning of mouse paired-box-containing gene (Pax)-4 from an islet beta cell line and deduced sequence of human Pax-4". Biochem. Biophys. Res. Commun. 242 (1): 176–80. doi:10.1006/bbrc.1997.7935. PMID 9439631. 
  3. ^ Inoue H, Nomiyama J, Nakai K, Matsutani A, Tanizawa Y, Oka Y (February 1998). "Isolation of full-length cDNA of mouse PAX4 gene and identification of its human homologue". Biochem. Biophys. Res. Commun. 243 (2): 628–33. doi:10.1006/bbrc.1998.8144. PMID 9480859. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.