Sir Patrick Hamilton (died 1520) was a Scottish nobleman. He was an illegitimate son of James Hamilton, 1st Lord Hamilton, and a younger brother of James Hamilton, 1st Earl of Arran. He was also nephew of King James IV of Scotland.
In March 1516, the infant James V of Scotland and the Governor, Regent Albany leased Patrick to rights to mine for gold, silver, tin and other metals on Crawford Moor and other places.[1] In 1520, as a result of rivalry between the Hamiltons and the 'Black' Douglases, he helped instigate the street brawl in Edinburgh known as 'Cleanse the Causeway'. The fight turned out badly for the Hamiltons, and Sir Patrick and about 70 others were killed. His heir was his oldest son, Sir James Hamilton of Kincavil.
A younger son, Master Patrick Hamilton went on to become one of the first preachers and Lutherans in Scotland, and in 1528 a martyr of the Scottish Reformation.