Parthenolide | |
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(1aR,7aS,10aS,10bS)-1a,5-dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one |
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Other names
4xi-Germacra-1(10), 11(13)-dien-12-oic acid, 4,5-epoxy-6.alpha.- |
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Identifiers | |
CAS number | 20554-84-1 |
PubChem | 5353864 |
UNII | 2RDB26I5ZB |
ChEMBL | CHEMBL540445 |
RTECS number | LY4220000 |
Properties | |
Molecular formula | C15H20O3 |
Molar mass | 248.32 g mol−1 |
Melting point |
113-115 |
(verify) (what is: / ?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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Infobox references |
Parthenolide is a sesquiterpene lactone of the germacranolide class which occurs naturally in the plant feverfew (Tanacetum parthenium), after which it is named. It is found in highest concentration in the flowers and fruit.
The plant is well known in natural medicine. Tablets and tinctures are used for the relief of migraine, to help prevent blood clots,[1] as an anti-inflammatory providing relief in cases of arthritis, to relieve some types of menstrual problems, and as a digestive aid. Parthenolide is the main active ingredient.
Many vendors of feverfew remedies specify the content of parthenolide in their products. Lack of solubility in water limits the benefits of parthenolide as a drug, and now motivates drug researchers to develop synthetic analogs that will be easier to absorb.