Pancreatic stellate cells (PaSCs or PSCs) are myofibroblast-like cells that can switch between the quiescent and activated phenotypes, like hepatic stellate cells.[2] PaSCs reside in exocrine areas of the pancreas. When activated, PaSCs undergo activation, migrate to the injured location, and participate in tissue repair activities, secreting ECM components. PaSCs may play a role in the pathogenesis of pancreatitis and pancreatic cancer.[1]