Palu'e Island is an island located north of Flores Island in the Flores Sea. It is part of Lesser Sunda Islands. Palu'e island is under the administrative region of Sikka regency of East Nusa Tenggara province, Indonesia.
The island has an area of 41 km² and population of 10,000 people in eight mountain villages. There are no roads or vehicles on the island. Palu'e can be reached from Maumere, a city in Flores, which takes six hours by wooden motorboat.
Rokatenda volcano is located in the northern region of Palu'e.