Palmatine
| palmatine |
|
2,3,9,10-tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium
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|
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| Identifiers |
| CAS number |
3486-67-7 |
| PubChem |
19009 |
| ChemSpider |
5224 |
| UNII |
G50C034217 |
| ChEMBL |
CHEMBL274189 |
| Jmol-3D images |
Image 1 |
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O(c1c4c(ccc1OC)CC3c2c(cc(OC)c(OC)c2)CCN3C4)C
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InChI=InChI=1/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3
Key: AEQDJSLRWYMAQI-UHFFFAOYAT
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| Properties |
| Molecular formula |
C21H24NO4+ |
| Molar mass |
342.4083 g/mol |
| Density |
1.23 g/cm3 |
| Boiling point |
482.9 °C at 760 mmHg
|
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
| Infobox references |
Palmatine is a protoberberine alkaloid found in several plants including Phellodendron amurense, Rhizoma coptidis/Coptis Chinensis and Corydalis yanhusuo.[1]
It is the major component of the protoberberine extract from Enantia chlorantha.[2]
It has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases.[3]
This compound could potentially be developed for the treatment of flavivirus infections[4]
See also
References
- ^ Wang YM, Zhao LB, Lin SL, Dong SS, An DK (1989). "[Determination of berberine and palmatine in cortex phellodendron and Chinese patent medicines by HPLC]" (in Chinese). Yao Xue Xue Bao = Acta Pharmaceutica Sinica 24 (4): 275–9. PMID 2816389.
- ^ Virtanen P., Njimi T.,Ekotto Mengata D.:Clinical trials of hepatitis cure with protoberberine alkaloids of Enantia Chlorantha (abstract) Eur.J.Clin.Pharmacol.36: A123, 1989b
- ^ Bhadra K, Kumar GS (January 2010). "Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: Binding aspects and implications for drug design". Medicinal Research Reviews: n/a. doi:10.1002/med.20202. PMID 20077560.
- ^ Jia F., Zou G., Fan J., Yuan Z."Identification of palmatine as an inhibitor of West Nile virus" Archives of Virology 2010 155:8 (1325-1329)