PTTG1IP
Pituitary tumor-transforming gene 1 protein-interacting protein is a protein that in humans is encoded by the PTTG1IP gene.[1][2][3]
The encoded protein, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates the nuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor by PTTG1. The gene product localizes to both the cytoplasm and nucleus. Its NLS is required for its own nuclear localization, the nuclear localization of PTTG1, and its interaction with PTTG1.[3]
Interactions
PTTG1IP has been shown to interact with PTTG1.[4]
References
- ^ Yaspo ML, Aaltonen J, Horelli-Kuitunen N, Peltonen L, Lehrach H (Jun 1998). "Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3". Genomics 49 (1): 133–6. doi:10.1006/geno.1998.5217. PMID 9570958.
- ^ Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (Jun 2000). "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
- ^ a b "Entrez Gene: PTTG1IP pituitary tumor-transforming 1 interacting protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=754.
- ^ Chien, W; Pei L (Jun. 2000). "A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product". J. Biol. Chem. (UNITED STATES) 275 (25): 19422–7. doi:10.1074/jbc.M910105199. ISSN 0021-9258. PMID 10781616.
Further reading
- Chien W, Pei L (2000). "A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product". J. Biol. Chem. 275 (25): 19422–7. doi:10.1074/jbc.M910105199. PMID 10781616.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Boelaert K, Tannahill LA, Bulmer JN, et al. (2003). "A potential role for PTTG/securin in the developing human fetal brain". FASEB J. 17 (12): 1631–9. doi:10.1096/fj.02-0948com. PMID 12958169.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Tfelt-Hansen J, Yano S, Bandyopadhyay S, et al. (2004). "Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells". Endocrinology 145 (9): 4222–31. doi:10.1210/en.2003-1661. PMID 15178645.
- Stock M, Schäfer H, Fliegauf M, Otto F (2005). "Identification of novel genes of the bone-specific transcription factor Runx2". J. Bone Miner. Res. 19 (6): 959–72. doi:10.1359/jbmr.2004.19.6.959. PMID 15190888.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Boelaert K, Smith VE, Stratford AL, et al. (2007). "PTTG and PBF repress the human sodium iodide symporter". Oncogene 26 (30): 4344–56. doi:10.1038/sj.onc.1210221. PMID 17297475.