PTGES2

Prostaglandin E synthase 2

PDB rendering based on 1z9h.
Identifiers
Symbols PTGES2; C9orf15; FLJ14038; GBF1; MGC11289; PGES2; mPGES-2
External IDs OMIM: 608152 MGI: 1917592 HomoloGene: 11819 GeneCards: PTGES2 Gene
EC number 5.3.99.3
Orthologs
Species Human Mouse
Entrez 80142 96979
Ensembl ENSG00000148334 ENSMUSG00000026820
UniProt Q9H7Z7 Q8BWM0
RefSeq (mRNA) NM_025072.5 NM_133783.2
RefSeq (protein) NP_945176 NP_598544.2
Location (UCSC) Chr 9:
130.88 – 130.89 Mb		 Chr 2:
32.25 – 32.26 Mb
PubMed search [1] [2]

Prostaglandin E synthase 2 is an enzyme that in humans is encoded by the PTGES2 gene.[1][2]

The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a interferon-gamma gamma-interferon-activated transcription element (GATE).[2]

Model organisms

Model organisms have been used in the study of PTGES2 function. A conditional knockout mouse line, called Ptges2tm1a(EUCOMM)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty two tests were carried out on mutant mice, but no significant abnormalities were observed.[5]

References

  1. ^ Tanikawa N, Ohmiya Y, Ohkubo H, Hashimoto K, Kangawa K, Kojima M, Ito S, Watanabe K (March 2002). "Identification and characterization of a novel type of membrane-associated prostaglandin E synthase". Biochem. Biophys. Res. Commun. 291 (4): 884–9. doi:10.1006/bbrc.2002.6531. PMID 11866447. 
  2. ^ a b "Entrez Gene: prostaglandin E synthase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80142. 
  3. ^ "Salmonella infection data for Ptges2". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MCKT/salmonella-challenge/. 
  4. ^ "Citrobacter infection data for Ptges2". Wellcome Trust Sanger Institute. http://www.sanger.ac.uk/mouseportal/phenotyping/MCKT/citrobacter-challenge/. 
  5. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. http://onlinelibrary.wiley.com/doi/10.1111/j.1755-3768.2010.4142.x/abstract. 
  6. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  7. ^ "International Knockout Mouse Consortium". http://www.knockoutmouse.org/martsearch/search?query=Ptges2. 
  8. ^ "Mouse Genome Informatics". http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4432215. 
  9. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M. et al. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMID 21677750.  edit
  10. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474: 262-263. doi:10.1038/474262a. http://www.nature.com/news/2011/110615/full/474262a.html. 
  11. ^ Collins FS, Rossant J, Wurst W (January 2007). A mouse for all reasons. Cell 128(1): 9-13. doi:10.1016/j.cell.2006.12.018 PMID 17218247. 
  12. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMID 21722353. http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21722353. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.