Prostaglandin E receptor 3

Prostaglandin E receptor 3 (subtype EP3)

Identifiers

PTGER3; EP3; EP3-I; EP3-II; EP3-III; EP3-IV; EP3e; MGC141828; MGC141829; MGC27302

External IDs

OMIM: 176806 MGI: 97795 HomoloGene: 105703 IUPHAR: EP₃ GeneCards: PTGER3 Gene

Gene Ontology
Molecular function	• ligand-dependent nuclear receptor activity • G-protein coupled receptor activity • prostaglandin E receptor activity
Cellular component	• nuclear envelope • plasma membrane • plasma membrane • integral to plasma membrane • integral to membrane
Biological process	• transcription, DNA-dependent • G-protein coupled receptor protein signaling pathway • cell death • positive regulation of fever generation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
71.32 – 71.51 Mb

Chr 3:
157.23 – 157.31 Mb

PubMed search

[1]

[2]

Prostaglandin E receptor 3, also known as EP₃, is a prostaglandin receptor, encoded by the PTGER3 gene.^[1]

1 Receptor
2 Variations
3 See also
4 References
5 External links
6 Further reading

Receptor

The receptor is a member of the G-protein coupled receptor family. It is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. In the stomach, it inhibits gastric acid secretions.

Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli.

Variations

Multiple alternatively spliced transcript variants encoding eight distinct isoforms have been reported.^[1]

References

^ ^a ^b "Entrez Gene: PTGER3 prostaglandin E receptor 3 (subtype EP3)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5733.

External links

"Prostanoid Receptors: EP₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2420.

Kotani M, Tanaka I, Ogawa Y et al. (1995). "Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions". Mol. Pharmacol. 48 (5): 869–79. PMID 7476918.
Duncan AM, Anderson LL, Funk CD et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family". Genomics 25 (3): 740–742. doi:10.1016/0888-7543(95)80022-E. PMID 7759114.
Schmid A, Thierauch KH, Schleuning WD, Dinter H (1995). "Splice variants of the human EP3 receptor for prostaglandin E2". Eur. J. Biochem. 228 (1): 23–30. doi:10.1111/j.1432-1033.1995.tb20223.x. PMID 7883006.
An S, Yang J, So SW et al. (1995). "Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals". Biochemistry 33 (48): 14496–14502. doi:10.1021/bi00252a016. PMID 7981210.
Regan JW, Bailey TJ, Donello JE et al. (1994). "Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini". Br. J. Pharmacol. 112 (2): 377–85. PMC 1910333. PMID 8075855. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1910333.
Yang J, Xia M, Goetzl EJ, An S (1994). "Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2". Biochem. Biophys. Res. Commun. 198 (3): 999–1006. doi:10.1006/bbrc.1994.1142. PMID 8117308.
Kunapuli SP, Fen Mao G, Bastepe M et al. (1994). "Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells". Biochem. J. 298 ( Pt 2): 263–7. PMC 1137934. PMID 8135729. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1137934.
Adam M, Boie Y, Rushmore TH et al. (1994). "Cloning and expression of three isoforms of the human EP3 prostanoid receptor". FEBS Lett. 338 (2): 170–174. doi:10.1016/0014-5793(94)80358-7. PMID 8307176.
Chang C, Negishi M, Nishigaki N, Ichikawa A (1997). "Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype". Biochem. J. 322 ( Pt 2): 597–601. PMC 1218231. PMID 9065782. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218231.
Kotani M, Tanaka I, Ogawa Y et al. (1997). "Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3)". Genomics 40 (3): 425–434. doi:10.1006/geno.1996.4585. PMID 9073510.
Ushikubi F, Segi E, Sugimoto Y et al. (1998). "Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3". Nature 395 (6699): 281–284. doi:10.1038/26233. PMID 9751056.
Bhattacharya M, Peri K, Ribeiro-da-Silva A et al. (1999). "Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope". J. Biol. Chem. 274 (22): 15719–15724. doi:10.1074/jbc.274.22.15719. PMID 10336471.
Liu J, Akahoshi T, Jiang S et al. (2000). "Induction of neutrophil death resembling neither apoptosis nor necrosis by ONO-AE-248, a selective agonist for PGE2 receptor subtype 3". J. Leukoc. Biol. 68 (2): 187–93. PMID 10947062.
Kurihara Y, Endo H, Kondo H (2001). "Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells". Inflamm. Res. 50 (1): 1–5. doi:10.1007/s000110050716. PMID 11235015.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Matsuoka Y, Furuyashiki T, Bito H et al. (2003). "Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4132–4137. doi:10.1073/pnas.0633341100. PMC 153060. PMID 12642666. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=153060.
Wing DA, Goharkhay N, Hanna M et al. (2003). "EP3-2 receptor mRNA expression is reduced and EP3-6 receptor mRNA expression is increased in gravid human myometrium". J. Soc. Gynecol. Investig. 10 (3): 124–129. doi:10.1016/S1071-5576(03)00007-8. PMID 12699873.
Abulencia JP, Gaspard R, Healy ZR et al. (2003). "Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells". J. Biol. Chem. 278 (31): 28388–28394. doi:10.1074/jbc.M301378200. PMID 12743126.
Richards JA, Brueggemeier RW (2003). "Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes". J. Clin. Endocrinol. Metab. 88 (6): 2810–2816. doi:10.1210/jc.2002-021475. PMID 12788892.
Moreland RB, Kim N, Nehra A et al. (2004). "Functional prostaglandin E (EP) receptors in human penile corpus cavernosum". Int. J. Impot. Res. 15 (5): 362–368. doi:10.1038/sj.ijir.3901042. PMID 14562138.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors

Class A:
Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3

Purinergic	Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)

Serotonin	(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)

Other	Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane

Other	Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate · Lysophosphatidic acid (1, 2, 3, 4, 5, 6) · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate

Peptide

Neuropeptide	B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)

Other	Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Chemokine · Cholecystokinin (A, B) · Endothelin (A, B) · Formyl peptide (1, 2, 3) · FSH · Galanin (1, 2, 3) · GHB receptor · Gonadotropin-releasing hormone (1, 2) · Ghrelin · Kisspeptin · Luteinizing hormone/choriogonadotropin · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Orexin (1, 2) · Oxytocin · Prokineticin (1, 2) · Prolactin-releasing peptide · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)

Miscellaneous

Orphan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)

Other	Adrenomedullin · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Protease-activated (1, 2, 3, 4) · SREB (1, 2, 3)

Class B: Secretin like

Orphan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)

Other	Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)

Other	Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4)

Class F:
Frizzled / Smoothened

Frizzled	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)

Smoothened	Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

Prostaglandin E receptor 3

Contents

Receptor

Variations

See also

References

External links

Further reading