HLA-C

Major histocompatibility complex, class I, C

Illustation of an HLA-C showing the HLA-B 'alpha' chain, ?2-Microglobulin, and the end of a peptide bound in the binding cleft.

Available structures
PDB	1IM9, 1QQD, 3BZF

Identifiers

Symbols

HLA-C; D6S204; FLJ27082; HLA-JY3; HLC-C; PSORS1

External IDs

OMIM: 142840 HomoloGene: 110784 GeneCards: HLA-C Gene

Gene Ontology
Molecular function	• MHC class I receptor activity
Cellular component	• extracellular region • plasma membrane • plasma membrane • integral to plasma membrane • membrane • integral to membrane • MHC class I protein complex
Biological process	• antigen processing and presentation of peptide antigen via MHC class I • immune response • immune response • cytokine-mediated signaling pathway • antigen processing and presentation • interspecies interaction between organisms • regulation of immune response • interferon-gamma-mediated signaling pathway • type I interferon-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
31.34 – 31.35 Mb

Chr 17:
35.4 – 35.4 Mb

PubMed search

[1]

[2]

HLA-C belongs to the MHC (human = HLA) class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.

HLA-C is a locus on chromosome 6, which encodes for a large number of HLA-C alleles that are Class-I MHC receptors. HLA-C is localized proximal to the HLA-B locus is located on the distal end of the HLA region. Most HLA Cw:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.

1 Disease Associations
- 1.1 By Serotype
- 1.2 By Allele
2 Nomenclature
3 Common Haplotype
4 Interactions
5 References
6 Further reading
7 External links

Disease Associations

By Serotype

Cw1: Multinodular goiters^[1]

By Allele

Cw*16: B chronic lymphocytic leukemia^[2]

Nomenclature

Cw*01

Cw1 Serotype: Cw*0102 and Cw*0109
Cw11 ?
Cw*0104 to *0108

Cw*02

Cw2 Serotype: Cw*0202 and *0208
Cw*0203 to *0207, and 0209

Cw*03

Cw9 Serotype: Cw*0303
Cw10 Serotype: Cw*0302, *0304, and *0306
Cw3 Serotype: Cw*0307
Cw*0305 and 0308

Cw*04

Cw4 Serotype: Cw*0401, *0407, and *0410

Cw*05

Cw5 Serotype: Cw*0501 and *0502
Cw*0503 to *506 and *0508 to *0510

Cw*06

Cw6 Serotype: Cw*0602 and *0605
Cw6*0603, *0604 and *0606 to *0611

Cw7 Serotype: Cw*0701 to *0706, *0712, *0714, *0716
Cw*0707 to *0711, *0713, *0715, and *0717 to *0729

Cw*08

Cw8 Serotype: Cw*0801, *0802 and *0803
Cw*805 to *0812

Cw*1202 to *1215

Cw*1402 to *1405

Cw*1501 to *1511

Cw*1601 to *1606

Cw*1701 to *1703

Cw*1801 and *1802

Common Haplotype

Cw4-B35 (Western Africa to Native Americans) Cw7-B7 (Western Eurasia, South Africa) Cw7-B8 (Western Eurasia) Cw1-B46 (China, Indochina) Cw5-B44 (Western Eurasia)

Interactions

HLA-C has been shown to interact with KIR2DL1.^[3]^[4]^[5]^[6] and with various members of the Leukocyte immunoglobulin-like receptor family, particularly the activating receptors LILRA1 and LILRA3 ^[7]

References

^ Ríos A, Rodríguez J, Moya M, Galindo P, Canteras M, Alvarez M, Parrilla P (2006). "Associations of HLA-C alleles with multinodular goiters: study in a population from southeastern Spain.". Arch Surg 141 (2): 123–8. doi:10.1001/archsurg.141.2.123. PMID 16490887.
^ Montes-Ares O, Moya-Quiles M, Montes-Casado M, Guerra-Pérez N, Campillo J, González C, López-Bermejo A, Tamayo M, Majado M, Parrado A, Muro M, Marín L, Alvarez-López M (2006). "Human leucocyte antigen-C in B chronic lymphocytic leukaemia.". Br J Haematol 135 (4): 517–9. doi:10.1111/j.1365-2141.2006.06334.x. PMID 17054674.
^ Boyson, Jonathan E; Erskine Robert, Whitman Mary C, Chiu Michael, Lau Julie M, Koopman Louise A, Valter Markus M, Angelisova Pavla, Horejsi Vaclav, Strominger Jack L (Dec. 2002). "Disulfide bond-mediated dimerization of HLA-G on the cell surface". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (25): 16180–5. doi:10.1073/pnas.212643199. ISSN 0027-8424. PMC 138585. PMID 12454284. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=138585.
^ Baba, E; Erskine R, Boyson J E, Cohen G B, Davis D M, Malik P, Mandelboim O, Reyburn H T, Strominger J L (Dec. 2000). "N-linked carbohydrate on human leukocyte antigen-C and recognition by natural killer cell inhibitory receptors". Hum. Immunol. (United States) 61 (12): 1202–18. doi:10.1016/S0198-8859(00)00184-1. ISSN 0198-8859. PMID 11163076.
^ Valés-Gómez, M; Reyburn H T, Mandelboim M, Strominger J L (Sep. 1998). "Kinetics of interaction of HLA-C ligands with natural killer cell inhibitory receptors". Immunity (UNITED STATES) 9 (3): 337–44. doi:10.1016/S1074-7613(00)80616-0. ISSN 1074-7613. PMID 9768753.
^ Fan, Q R; Long E O, Wiley D C (May. 2001). "Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex". Nat. Immunol. (United States) 2 (5): 452–60. doi:10.1038/87766. ISSN 1529-2908. PMID 11323700.
^ Jones DC, Kosmoliaptsis V, Apps R, Lapaque N, Smith I, Kono A, Chang C, Boyle LH, Taylor CJ, Trowsdale J, Allen RL (Mar 2011). "HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding". J Immunol 186 (5): 2990–7. doi:10.4049/jimmunol.1003078. PMID 21270408.

External links

Surface antigens

Major histocompatibility complex/
Human leukocyte antigen

MHC class I	HLA-A • HLA-B • HLA-C • HLA-E • HLA-F • HLA-G

MHC class II	HLA-DM (α, β) • HLA-DO (α, β) • HLA-DP (α1, β1) • HLA-DQ (α1, α2, β1, β2, β3) • HLA-DR (α, β1, β3, β4, β5) Minor histocompatibility antigen

Other

Arrestin - Calgranulin - Blood group antigens - Cell adhesion molecules - Differentiation antigens

M: LMC

cell/phys/auag/auab/comp, igrc

imdf/ipig/hyps/tumr

proc, drug(L3/4)