PRPSAP1

Phosphoribosyl pyrophosphate synthetase-associated protein 1

PDB rendering based on 2c4k.

Available structures
PDB	2c4k

Identifiers

Symbols

PRPSAP1; PAP39

External IDs

OMIM: 601249 MGI: 1915013 HomoloGene: 55687 GeneCards: PRPSAP1 Gene

Gene Ontology
Molecular function	• magnesium ion binding • ribose phosphate diphosphokinase activity • enzyme inhibitor activity • protein binding • identical protein binding
Cellular component	• protein complex
Biological process	• nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • nucleotide biosynthetic process • negative regulation of catalytic activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
74.31 – 74.38 Mb

Chr 11:
116.33 – 116.36 Mb

PubMed search

[1]

[2]

Phosphoribosyl pyrophosphate synthetase-associated protein 1 is an enzyme that in humans is encoded by the PRPSAP1 gene.^[1]^[2]

References

^ Ishizuka T, Ahmad I, Kita K, Sonoda T, Ishijima S, Sawa K, Suzuki N, Tatibana M (Jan 1997). "The human phosphoribosylpyrophosphate synthetase-associated protein 39 gene (PRPSAP1) is located in the chromosome region 17q24-q25". Genomics 33 (2): 332–4. doi:10.1006/geno.1996.0207. PMID 8660991.
^ "Entrez Gene: PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5635.

Tatibana M, Kita K, Taira M, et al. (1995). "Mammalian phosphoribosyl-pyrophosphate synthetase.". Adv. Enzyme Regul. 35: 229–49. doi:10.1016/0065-2571(94)00017-W. PMID 7572345.
Kita K, Ishizuka T, Ishijima S, et al. (1994). "A novel 39-kDa phosphoribosylpyrophosphate synthetase-associated protein of rat liver. Cloning, high sequence similarity to the catalytic subunits, and a negative regulatory role.". J. Biol. Chem. 269 (11): 8334–40. PMID 8132556.
Ishizuka T, Kita K, Sonoda T, et al. (1996). "Cloning and sequencing of human complementary DNA for the phosphoribosylpyrophosphate synthetase-associated protein 39.". Biochim. Biophys. Acta 1306 (1): 27–30. PMID 8611620.
Ishijima S, Asai T, Kita K, et al. (1997). "Partial reconstitution of mammalian phosphoribosylpyrophosphate synthetase in Escherichia coli cells. Coexpression of catalytic subunits with the 39-kDa associated protein leads to formation of soluble multimeric complexes of various compositions.". Biochim. Biophys. Acta 1342 (1): 28–36. PMID 9366267.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.

PDB gallery

2c4k: CRYSTAL STRUCTURE OF HUMAN PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE-ASSOCIATED PROTEIN 39 (PAP39)

PRPSAP1

References

Further reading