PRIMA1

Proline rich membrane anchor 1
Identifiers
Symbols PRIMA1; PRIMA
External IDs OMIM: 613851 MGI: 1926097 HomoloGene: 15783 GeneCards: PRIMA1 Gene
Orthologs
Species Human Mouse
Entrez 145270 170952
Ensembl ENSG00000175785 ENSMUSG00000041669
UniProt Q86XR5 Q810F0
RefSeq (mRNA) NM_178013 NM_133364.2
RefSeq (protein) NP_821092 NP_579942.2
Location (UCSC) Chr 14:
94.18 – 94.25 Mb		 Chr 12:
104.44 – 104.48 Mb
PubMed search [1] [2]

Proline-rich membrane anchor 1, also known as PRiMA, is a protein that in humans is encoded by the PRIMA1 gene.[1][2] PRiMA functions to organize acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes.[1]

References

  1. ^ a b "Entrez Gene: proline rich membrane anchor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=145270. 
  2. ^ Perrier AL, Massoulié J, Krejci E (2002). "PRiMA: the membrane anchor of acetylcholinesterase in the brain.". Neuron 33 (2): 275–85. doi:10.1016/S0896-6273(01)00584-0. PMID 11804574. 

Further reading

  • Perrier NA, Khérif S, Perrier AL, et al. (2003). "Expression of PRiMA in the mouse brain: membrane anchoring and accumulation of 'tailed' acetylcholinesterase.". Eur. J. Neurosci. 18 (7): 1837–47. doi:10.1046/j.1460-9568.2003.02914.x. PMID 14622217. 
  • Xie HQ, Siow NL, Peng HB, et al. (2005). "Regulation of PRiMA: membrane anchor of acetylcholinesterase (AChE) in neuron and muscle.". Chem. Biol. Interact. 157-158: 432. doi:10.1016/j.cbi.2005.10.093. PMID 16429581. 
  • Vanaja DK, Ballman KV, Morlan BW, et al. (2006). "PDLIM4 repression by hypermethylation as a potential biomarker for prostate cancer.". Clin. Cancer Res. 12 (4): 1128–36. doi:10.1158/1078-0432.CCR-05-2072. PMID 16489065. 
  • Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Xie HQ, Choi RC, Leung KW, et al. (2009). "Transcriptional regulation of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase in neuron: an inductive effect of neuron differentiation.". Brain Res. 1265: 13–23. doi:10.1016/j.brainres.2009.01.065. PMID 19368807. 
  • Xie HQ, Liang D, Leung KW, et al. (2010). "Targeting acetylcholinesterase to membrane rafts: a function mediated by the proline-rich membrane anchor (PRiMA) in neurons.". J. Biol. Chem. 285 (15): 11537–46. doi:10.1074/jbc.M109.038711. PMID 20147288.