PRDM2

PR domain containing 2, with ZNF domain

Rendering based on PDB 2JV0.
Identifiers
Symbols PRDM2; HUMHOXY1; KMT8; MTB-ZF; RIZ; RIZ1; RIZ2
External IDs OMIM: 601196 MGI: 107628 HomoloGene: 40822 GeneCards: PRDM2 Gene
EC number 2.1.1.43
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 7799 110593
Ensembl ENSG00000116731 ENSMUSG00000057637
UniProt Q13029 n/a
RefSeq (mRNA) NM_001007257.2 NM_001081355.3
RefSeq (protein) NP_001007258.1 NP_001074824.3
Location (UCSC) Chr 1:
14.03 – 14.15 Mb		 Chr 4:
142.7 – 142.8 Mb
PubMed search [1] [2]

PR domain zinc finger protein 2 is a protein that in humans is encoded by the PRDM2 gene.[1][2]

This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Three transcript variants encoding different isoforms have been found for this gene.[2]

Contents

Interactions

PRDM2 has been shown to interact with Estrogen receptor alpha[3] and Retinoblastoma protein.[1]

References

  1. ^ a b Buyse IM, Shao G, Huang S (Jun 1995). "The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein". Proc Natl Acad Sci U S A 92 (10): 4467–71. doi:10.1073/pnas.92.10.4467. PMC 41965. PMID 7538672. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41965. 
  2. ^ a b "Entrez Gene: PRDM2 PR domain containing 2, with ZNF domain". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7799. 
  3. ^ Abbondanza, C; Medici N, Nigro V, Rossi V, Gallo L, Piluso G, Belsito A, Roscigno A, Bontempo P, Puca A A, Molinari A M, Moncharmont B, Puca G A (Mar. 2000). "The retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (7): 3130–5. doi:10.1073/pnas.050015697. ISSN 0027-8424. PMC 16204. PMID 10706618. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16204. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.