PRAM1
PML-RARA-regulated adapter molecule 1 is a protein that in humans is encoded by the PRAM1 gene.[1][2][3]
The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).[3]
Interactions
PRAM1 has been shown to interact with TRIM27.[4]
References
- ^ Moog-Lutz C, Peterson EJ, Lutz PG, Eliason S, Cave-Riant F, Singer A, Di Gioia Y, Dmowski S, Kamens J, Cayre YE, Koretzky G (Jun 2001). "PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells". J Biol Chem 276 (25): 22375–81. doi:10.1074/jbc.M011683200. PMID 11301322.
- ^ Clemens RA, Newbrough SA, Chung EY, Gheith S, Singer AL, Koretzky GA, Peterson EJ (Dec 2004). "PRAM-1 Is Required for Optimal Integrin-Dependent Neutrophil Function". Mol Cell Biol 24 (24): 10923–32. doi:10.1128/MCB.24.24.10923-10932.2004. PMC 533979. PMID 15572693. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=533979.
- ^ a b "Entrez Gene: PRAM1 PML-RARA regulated adaptor molecule 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84106.
- ^ Cao, T; Duprez E, Borden K L, Freemont P S, Etkin L D (May. 1998). "Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML". J. Cell. Sci. (ENGLAND) 111 ( Pt 10): 1319–29. ISSN 0021-9533. PMID 9570750.
Further reading
- Boddy MN, Howe K, Etkin LD et al. (1996). "PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia". Oncogene 13 (5): 971–82. PMID 8806687.
- Cao T, Duprez E, Borden KL et al. (1998). "Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML". J. Cell. Sci. 111 ( Pt 10): 1319–29. PMID 9570750.
- Khan MM, Nomura T, Kim H et al. (2001). "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression". Mol. Cell 7 (6): 1233–43. doi:10.1016/S1097-2765(01)00257-X. PMID 11430826.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Denis FM, Benecke A, Di Gioia Y et al. (2005). "PRAM-1 potentiates arsenic trioxide-induced JNK activation". J. Biol. Chem. 280 (10): 9043–8. doi:10.1074/jbc.M413564200. PMID 15637062.
- Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Rossi V, Levati L, Biondi A (2006). "Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR". Methods Mol. Med. 125: 115–26. PMID 16502581.
- Mokany E, Todd AV, Fuery CJ, Applegate TL (2006). "Diagnosis and monitoring of PML-RARalpha-positive acute promyelocytic leukemia by quantitative RT-PCR". Methods Mol. Med. 125: 127–47. PMID 16502582.
- Heuer K, Sylvester M, Kliche S et al. (2006). "Lipid-binding hSH3 domains in immune cell adapter proteins". J. Mol. Biol. 361 (1): 94–104. doi:10.1016/j.jmb.2006.06.004. PMID 16831444.